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Displaying results 111 - 120 of 10000 in total
  1. Drug

    Capecitabine

    go.drugbank.com/drugs/DB01101
    ApprovedInvestigational

    Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. … Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers.

    Synonyms: Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate, pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamateCategories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 Substrates
  2. Drug

    Uridine triacetate

    go.drugbank.com/drugs/DB09144
    Approved

    It reduces toxicity and cell-death associated with two cytotoxic intermediates: 5-fluoro-2'-deoxyuridine-5'-monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). … By pre-administering with uridine (as the prodrug uridine triacetate), higher doses of 5-FU can be given allowing for improved efficacy and a reduction in toxic side effects [A18578].

    Synonyms: 2',3',5'-tri-O-acetyluridine, 2',3',5'-TriacetyluridineCategories: Heterocyclic Compounds, 1-Ring
  3. Drug

    Foxy-5

    go.drugbank.com/drugs/DB13034
    Investigational

    Foxy-5 has been used in trials studying the treatment of Prostate Cancer, Colorectal Cancer, Metastatic Colon Cancer, Metastatic Breast Cancer, and Metastatic Prostate Cancer.

    Synonyms: Foxy-5
  4. Drug

    Biperiden

    go.drugbank.com/drugs/DB00810
    ApprovedInvestigationalWithdrawn

    A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. … It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.

    Synonyms: 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol, alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanolCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2D6 Inhibitors
  5. Drug

    5-Bromonicotinamide

    go.drugbank.com/drugs/DB01854
    Experimental

    Synonyms: 5-Bromonicotinamide
  6. Drug

    5-Bromothienyldeoxyuridine

    go.drugbank.com/drugs/DB03804
    Experimental

    Synonyms: 5-Bromothienyldeoxyuridine
  7. Drug

    5-Oxoprolinal

    go.drugbank.com/drugs/DB03901
    Experimental

    Synonyms: 5-Oxoprolinal, 5-KetoprolinalCategories: Pyroglutamyl-Peptidase I, antagonists & inhibitors
  8. Drug

    5'-Guanylylmethylenebisphosphonate

    go.drugbank.com/drugs/DB03725
    Experimental

    Synonyms: 5'-Guanosyl-methylene-triphosphate, 5'-GuanylylmethylenebisphosphonateCategories: Heterocyclic Compounds, 2-Ring
  9. Drug

    5'-S-ethyl-5'-thioadenosine

    go.drugbank.com/drugs/DB07052
    Experimental

    Synonyms: 5'-S-ethyl-5'-thioadenosine
  10. Drug

    5'-FLUORO-2',5'-DIDEOXYADENOSINE

    go.drugbank.com/drugs/DB07170
    Experimental

    Synonyms: 5'-FLUORO-2',5'-DIDEOXYADENOSINE