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Linaclotide
go.drugbank.com/drugs/DB08890ApprovedInvestigational[A260271] It gained EMA and Health Canada approval on November 26, 2012 [L47216] and December 3, 2013,[L47221] respectively. … Linaclotide is a synthetic 14-amino acid cyclic peptide [A260271] and first-in-class guanylate cyclase-C (G-CC) agonist.
Salts: Linaclotide acetateCategories: Alimentary Tract and Metabolism, Amino Acids, Peptides, and ProteinsMotixafortide
go.drugbank.com/drugs/DB14939ApprovedInvestigational[L48116] When administered alongside [filgrastim], another agent used to aid in stem cell collection, motixafortide enabled the collection of an adequate number of stem cells in ~92% of patients within … is commonly employed in the context of hematologic cancers - high-dose chemotherapy regimens destroy cancerous blood cells, which are then replaced via infusion of the patient's own stem cells (i.e. an
Salts: Motixafortide acetateCategories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsAfamelanotide
go.drugbank.com/drugs/DB04931Approved[L9092] Despite its relatively recent approval, afamelanotide has been available for use as an orphan drug in both the US and EU since 2008.[L9122,L9125] … [L9086] It differs structurally from its endogenous counterpart by only two amino acids - these structural differences improve biological efficacy by imparting a greater affinity for its target and a longer
Salts: Afamelanotide acetateCategories: Indicators and Reagents, Amino Acids, Peptides, and ProteinsBazedoxifene
go.drugbank.com/drugs/DB06401ApprovedInvestigationalIt is approved in the European Union (marketed in Italy and Spain) and Japan as monotherapy. … In 2013, the combination product containing conjugated estrogens and bazedoxifene was approved by the FDA for the treatment of moderate to severe vasomotor symptoms associated with menopause, as well as
Salts: Bazedoxifene acetateCategories: Genito Urinary System and Sex Hormones, conjugated estrogens and bazedoxifeneMacimorelin
go.drugbank.com/drugs/DB13074Approvedand diagnosis of AGHD. … They include treatment for growth retardation in children and cachexia associated with chronic disease such as AIDS and cancer.
Salts: Macimorelin acetateCategories: Amino Acids, Peptides, and ProteinsRusfertide
go.drugbank.com/drugs/DB17724ApprovedInvestigational[L64098] Rusfertide is administered by subcutaneous injection and titrated to maintain hematocrit below 45%. … [L64098] It is a synthetic cyclic peptide that blocks the iron transporter ferroportin, reducing the availability of iron for red blood cell production and lowering hematocrit.
Salts: Rusfertide acetateCategories: Blood and Blood Forming Organs, Amino Acids, Peptides, and ProteinsSetmelanotide
go.drugbank.com/drugs/DB11700ApprovedInvestigational[A224449] Earlier attempts at agonizing MC4R (such as LY2112688) lead to successful weight loss, but also an increase in blood pressure and heart rate. … [L24474] It is an agonist of the melanocortin 4 receptor.
Salts: Setmelanotide acetateCategories: Alimentary Tract and Metabolism, Amino Acids, Peptides, and ProteinsBulevirtide
go.drugbank.com/drugs/DB15248ApprovedInvestigationalHepatitis D is considered the most severe type of viral hepatitis and leads to the rapid development of cirrhosis, severe decompensation of liver function, and an increased risk of mortality. … [L30215] In the USA, bulevirtide has been granted Orphan Drug Designation and Breakthrough Therapy Designation.
Salts: Bulevirtide acetateCategories: Amino Acids, Peptides, and ProteinsNafarelin
go.drugbank.com/drugs/DB00666ApprovedInvestigationalNafarelin has been used in the treatments of central precocious puberty and endometriosis.
Salts: Nafarelin acetateCategories: Pituitary and Hypothalamic Hormones and Analogues, Sex Hormones and Insulins