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Ancestim
go.drugbank.com/drugs/DB09103ApprovedWithdrawnIt is a 166 amino acid protein produced by E. coli with an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal … Ancestim is a non-glycosylated recombinant methionyl human stem cell factor.
Ecamsule
go.drugbank.com/drugs/DB09534ApprovedEcamsule has been approved for use in the U.S. since 2006, but only at a specific concentration and only in a few products manufactured by L'Oreal. … Ecamsule is an organic compound which is added to many sunscreens to filter out UVA rays. It is a benzylidene camphor derivative, many of which are known for their excellent photostability.
Categories: Compounds used in a research, industrial, or household settingLeucovorin
go.drugbank.com/drugs/DB00650ApprovedInvestigationalLeucovorin, also known as folinic acid or citrovorum factor, is a reduced form of folic acid that serves as a vital coenzyme in nucleic acid synthesis. … [L56091, L56092] Historically developed in 1945, leucovorin has long been a staple on the World Health Organization’s List of Essential Medicines.
Categories: Compounds used in a research, industrial, or household setting, Vitamin B ComplexProducts: Leucovorin Calcium Tab 5mg, FOLINATO DE CALCIO (EQUIVALENTE A ACIDO FOLINICO 50 MG/5MLErtugliflozin
go.drugbank.com/drugs/DB11827ApprovedInvestigationalErtugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus.
Sibeprenlimab
go.drugbank.com/drugs/DB18919ApprovedInvestigationalSibeprenlimab is a Proliferation Inducing Ligand (APRIL) blocker.[L54633] APRIL is a member of the tumour necrosis factor superfamily that regulates and modulates activated B cells. … [A274848, A274853, A274858] Elevated APRIL levels are often observed in inflammatory disorders, including immunoglobulin A nephropathy (IgAN).
Axicabtagene ciloleucel
go.drugbank.com/drugs/DB13915ApprovedInvestigationalThe drug has a unique mechanism of action, as it utilizes the patient's own T cells, which play a central role in immune response to cancer. … [L40054] The development of resulted from early preclinical studies conducted by a group of researchers at the National Cancer Institute (NCI), who demonstrated that T cells expressing an anti-CD19 CAR
Categories: Antigens, Differentiation, B-LymphocyteSynonyms: Autologous T cells transduced with retroviral vector encoding an anti-CD-19 CD28/CD3-zeta chimeric antigen receptorTetrofosmin
go.drugbank.com/drugs/DB11180ApprovedTetrofosmin is used in conjunction with technetium Tc-99m as a radiopharmaceutical.[A7788] … It presents a molecular formula of 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane. Tetrofosmin is part of the group of diphosphines.
Guselkumab
go.drugbank.com/drugs/DB11834ApprovedInvestigationalGuselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. … IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation [A20357].
Pinaverium
go.drugbank.com/drugs/DB09090ApprovedInvestigationalPinaverium is a spasmolytic agent used for functional gastrointestinal disorders. It is a quaternary ammonium compound that acts as an atypical calcium antagonist to restore normal bowel function. … Pinaverium bromide is the common ingredient in formulations, mostly as oral tablets.
Acellular nerve allograft
go.drugbank.com/drugs/DB30293ApprovedInvestigationalApproved by the FDA under a Biologics License Application (BLA) as an acellular nerve scaffold for the treatment of adult and pediatric patients (aged ≥1 month) with sensory, mixed, and motor peripheral