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Afamelanotide
go.drugbank.com/drugs/DB04931ApprovedAfamelanotide is a first-in-class, synthetic, 13-amino acid peptide analogue of the endogenous alpha melanocyte-stimulating hormone (α-MSH). … FDA approval in October 2019.
Categories: Compounds used in a research, industrial, or household settingSynonyms: MT-I, Melanotan IAbacavir
go.drugbank.com/drugs/DB01048ApprovedInvestigationalIn vivo, abacavir sulfate dissociates to its free base, abacavir. … Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring.
Mixtures: N/A, ARTEVIR LCategories: Antivirals used in combination for the treatment of HIV infectionsAcetrizoic acid
go.drugbank.com/drugs/DB09347ApprovedWithdrawn[L1704] Acetrizoic acid presents, in the FDA records, a category of drug substance with an inactive status.[L1703] … [A32135] It was first synthesized by Wallingford in 1953[A32136] and it was filled in the FDA by the Johnson & Johnson subsidiary, Cilag Chemie AG, on February 8th, 1978.
Categories: Compounds used in a research, industrial, or household settingTocopherol
go.drugbank.com/drugs/DB11251ApprovedInvestigationalTocopherol, as a group, is composed of soluble phenolic compounds that consist of a chromanol ring and a 16-carbon phytyl chain. … [A32436] It is currently under the list of substances generally recognized as safe (GRAS) in the FDA for the use of human consumption.[L2114]
Mixtures: Vital-D Rx, RenaPlex-DCategories: Compounds used in a research, industrial, or household settingPeginterferon alfa-2b
go.drugbank.com/drugs/DB00022ApprovedInvestigationalIn a joint recommendation published in 2016, the American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) no longer recommend Peginterferon alfa … HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of all chronic HCV patients [L852].
Categories: Compounds used in a research, industrial, or household setting, Interferon Type ISynonyms: PEG-IFN-α-2bDostarlimab
go.drugbank.com/drugs/DB15627ApprovedInvestigationalA prospective phase II study in patients with mismatch repair-deficient locally advanced rectal cancer resulted in all twelve patients exhibiting a complete clinical response.[A248905] … [L33340] This indication was granted full FDA approval on February 10, 2023.[L45161] Dostarlimab-gxly was granted second accelerated approval for the treatment of solid tumours in the same month.
Categories: PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsBronopol
go.drugbank.com/drugs/DB13960ApprovedL4873] and in other products where it may not primarily be used in the role of a non-medicinal preservative antimicrobial [L4874]. … First synthesized in 1897, bronopol was primarily used as a preservative for pharmaceuticals and was registered in the United States in 1984 for use in industrial bactericides, slimicides and preservatives
Categories: Compounds used in a research, industrial, or household settingPidolic acid
go.drugbank.com/drugs/DB03088ApprovedInvestigationalPidolic acid, in general, is found in large quantities in brain tissue and other tissues in bound form, like skin [L2729]. … Pidolic acid is a naturally occurring but little-studied amino acid derivative that can be formed enzymatically or non-enzymatically and participates as a biological intermediate with unique pharmacodynamics
Synonyms: 5-L-oxoproline, 5-oxo-L-prolineDoxercalciferol
go.drugbank.com/drugs/DB06410ApprovedInvestigationalDoxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring, biologically active form of vitamin … D2.
Synonyms: 1-Hydroxyvitamin D2, 1α-hydroxyvitamin D2Categories: Vitamin D and AnaloguesPolycarbophil
go.drugbank.com/drugs/DB09311ApprovedWithdrawnIt is insoluble in water, dilute acids, and dilute alkali. … Polycarbophil calcium is a synthetic polymer manufactured from the cross-linking of polyacrylic acid with divinyl glycol and a calcium counter-ion.
Categories: Compounds used in a research, industrial, or household setting