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Efmoroctocog alfa
go.drugbank.com/drugs/DB11607ApprovedInvestigationalVIII, but does not contain the B-domain, which has no known biological function, and [DB13192], which is purified endogenous Factor VIII from human pooled blood and contains both A- and B-subunits. … Efmoroctocog alfa is a first commercially available rFVIII-Fc fusion protein (rFVIIIFc) where the conjugated molecule of rFVIII to polyethylene glycol is covalently fused to the dimeric Fc domain of human
Categories: Human Antihemophilic FactorsDabigatran etexilate
go.drugbank.com/drugs/DB06695ApprovedInvestigationalDabigatran etexilate is an oral prodrug that is hydrolyzed to the competitive and reversible direct thrombin inhibitor [dabigatran].
Categories: Blood and Blood Forming OrgansSimoctocog alfa
go.drugbank.com/drugs/DB09108ApprovedFull human post-translational modifications via elimination of potentially immunogenic glycosylation patterns found in non-human cell lines led to decreased immunogenicity and longer half-life [A31525] … Simoctocog alfa is a fourth-generation BDD FVIII product made in the human embryonic kidney (HEK) cell line.
Categories: Amino Acids, Peptides, and ProteinsTuroctocog alfa pegol
go.drugbank.com/drugs/DB14738ApprovedInvestigationalTuroctocog alfa is produced in Chinese hamster ovary (CHO) cells without addition of any human or animal-derived materials [F3685]. … Fundamentally, the N8-GP moiety is identical to [turoctocog alfa], a recombinant human clotting factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the
Categories: Amino Acids, Peptides, and ProteinsSusoctocog alfa
go.drugbank.com/drugs/DB11606ApprovedInvestigationalThese autoantibodies neutralize circulating human factor VIII and create a functional deficiency of this procoagulant protein. … The recombinant porcine sequence allows less susceptibility to inactivation by circulating human factor VIII antibodies.
Categories: Blood and Blood Forming OrgansD-alpha-Tocopherol acetate
go.drugbank.com/drugs/DB14002ApprovedNutraceuticalVet approvedAlpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements. … of different conditions like cardiovascular disease, ocular conditions, diabetes, cancer and more.
Mixtures: Multi Vitamin and Mineral vitamin, Iron With Vitamins C and E - TabCategories: Diet, Food, and NutritionDanaparoid
go.drugbank.com/drugs/DB06754ApprovedWithdrawnThe active constituents are heparan, dermatan and [DB09301] [T28], and they are isolated from the porcine intestinal mucosa [FDA Label]. … Danaparoid sodium is the common salt form in therapeutic preparations and is typically administered subcutaneously.
Categories: Heparin and similars, Blood and Blood Forming OrgansNafamostat
go.drugbank.com/drugs/DB12598InvestigationalIt has been used in trials studying the prevention of Liver Transplantation and Postreperfusion Syndrome. … The use of nafamostat in Asian countries is approved as an anticoagulant therapy for patients undergoing continuous renal replacement therapy due to acute kidney injury.
Crotalus atrox antivenin
go.drugbank.com/drugs/DB13892ApprovedThe final purified antivenin product is produced by mixing other different monospecific snake antivenins and isolating the antivenin of interest through fractionation and chromatography techniques. … The majority of people bitten are males and about 50% occur in the age group of 18 to 28 [F113].