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Calfactant
go.drugbank.com/drugs/DB06415ApprovedInvestigationalCalfactant is a sterile, non-pyrogenic lung surfactant intended for intratracheal instillation. … proteins B and C.
Synonyms: SF-RI 1Products: INFASURF 35 MG/ML INTRATRAKEAL SÜSPANSIYON,3 ML, INFASURF 35 MG/ML INTRATRAKEAL SÜSPANSIYON ,6 MLLeniolisib
go.drugbank.com/drugs/DB16217ApprovedInvestigationalLeniolisib is a potent and selective inhibitor of phosphoinositide 3-kinase δ (PI3Kδ). … [L45758] APDS is a primary immunodeficiency caused by mutations in genes encoding the PI3Kδ, thereby increasing the activity of PI3Kδ, causing immune dysfunction, and elevating susceptibility to infections
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesTafasitamab
go.drugbank.com/drugs/DB15044ApprovedInvestigationalTafasitamab is a humanized, CD19-directed cytolytic monoclonal antibody intended for the treatment of B-cell malignancies. … [L15292,A191829] The CD19 surface protein is highly expressed on the surface of B-cells, where it appears to play a role in enhancing B-cell receptor signaling.
Categories: Lymphoma, B-CellmRNA-1345
go.drugbank.com/drugs/DB18739ApprovedInvestigationalmRNA-1345 is a nucleoside modified mRNA encoding the F-glycoprotein from RSV subtype A stabilized in its prefusion conformation.[L53393] It is the primary ingredient of the RSV vaccine mRESVIA. … [L53403,L53393] It is additionally under investigation for maternal use and use in children.[A274028,L53438,L53443]
Synonyms: Respiratory syncytial virus pre-fusion glycoprotein F mRNADoxecitine
go.drugbank.com/drugs/DB02594ApprovedInvestigationalDoxecitine is a synthetic form of the naturally occurring pyrimidine deoxyribonucleoside deoxycytidine. … This combination is the first and only approved treatment for Thymidine Kinase 2 deficiency.[L54613, L54618]
Categories: Heterocyclic Compounds, 1-RingSynonyms: 1-(2-Deoxy-β-D-ribofuranosyl)cytosine, 2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-Duvelisib
go.drugbank.com/drugs/DB11952ApprovedInvestigationalDuvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma … All the work around duvelisib showed that this agent is a potent inhibitor of both forms.[A39025] Duvelisib was developed by Verastem, Inc and FDA approved on September 24, 2018.[L4585]
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSodium molybdate
go.drugbank.com/drugs/DB14496ApprovedSynonyms: Sodium molybdate(VI)Mixtures: VI-MINERAL 30 CIGNEME TABLETI, Advanced B & T FormulaZiprasidone
go.drugbank.com/drugs/DB00246ApprovedInvestigational[A180748] Although ziprasidone is classified as an atypical antipsychotic, it appears to have a lower incidence of metabolic adverse effects compared to other medications in the same class.[A190525] … [A190534,A190537] Ziprasidone is used to treat schizophrenia and bipolar disorder.
Categories: Cytochrome P-450 Substrates, Adrenergic alpha-1 Receptor AntagonistsProducts: GEODON® CAPSULAS 80 MG, ICIN KURU TOZ ICEREN FLAKON 20MG/ML FLAKON, 1 ADETFomivirsen
go.drugbank.com/drugs/DB06759ApprovedWithdrawnFomivirsen is a antisense 21 mer phosphorothioate oligonucleotide. … It is an antiviral agent that was used in the treatment of cytomegalovirus retinitis (CMV) in immunocompromised patients, including those with AIDS.
Categories: Compounds used in a research, industrial, or household settingTideglusib
go.drugbank.com/drugs/DB12129ApprovedInvestigationalWithdrawnIt is reported to be a potent anti-inflammatory and neuroprotective that is a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3). … [A31601] Tideglusib is being developed by the Spanish pharmaceutic company Zeltia group and its current status is withdrawn for the treatment of Alzheimer's disease as of 2012.
Synonyms: 4-BENZYL-2-(A-NAPHTYL)-1,2,4-THIADIAZOLIDINE-3,5-DIONE, 4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dioneCategories: Heterocyclic Compounds, 1-Ring, Glycogen Synthase Kinase 3, antagonists & inhibitors