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Dorocubicel
go.drugbank.com/drugs/DB19448ApprovedDorocubicel is a preparation of cryopreserved allogeneic umbilical cord-derived hematopoietic stem cells and blood progenitors expanded ex vivo using UM-171. It is one component of a cell therapy, Zemcelpro, that also contains unexpanded...
Sparsentan
go.drugbank.com/drugs/DB12548ApprovedInvestigational[A257330,L45300] Sparsentan is first in its class and orally active, and was created by merging the structural elements of [irbesartan], an AT<sub>1</sub>R antagonist, and biphenylsulfonamide, an ET<sub … [L45300,L45315] In September 2024, it was granted full approval for an expanded indication.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesDifamilast
go.drugbank.com/drugs/DB14987ApprovedInvestigational[L56052, A275420] This skin disease occurs most frequently in children and can have an onset as early as within the first 2 years of life. … [L55042, A275424, A275420] As difamilast's mechanism of action involves the inhibition of PDE4, the inhibition leads to an increase in intracellular cyclic AMP and a subsequent decrease in the production
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InducersDenufosol
go.drugbank.com/drugs/DB04983InvestigationalDenufosol was an inhaled drug used for the treatment of cystic fibrosis (CF), showing various improvements in lung function during a phase III clinical trial.
Vonoprazan
go.drugbank.com/drugs/DB11739ApprovedInvestigationalUnlike proton-pump inhibitors, PCABs are not affected by CYP2C19 genetic polymorphisms and do not require acid-resistant formulations. … PCABs represent an alternative to proton-pump inhibitors for the treatment of acid-related disorders.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesOrphenadrine
go.drugbank.com/drugs/DB01173ApprovedInvestigationalA muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsAtracurium besylate
go.drugbank.com/drugs/DB00732ApprovedA non-depolarizing neuromuscular blocking agent with short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide clinical advantage over alternate no...
Synonyms: Besilato de atracurioTazobactam
go.drugbank.com/drugs/DB01606ApprovedInvestigationalTazobactam is an antibiotic of the beta-lactamase inhibitor class that prevents the breakdown of other antibiotics by beta-lactamase enzyme producing organisms.
Mixtures: AUROTAZ-P 4.5 G, Aurotaz-P Powder for Injections 4.5 gSnail, unspecified
go.drugbank.com/drugs/DB14245ApprovedInvestigationalSnail, unspecified is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.
Aluminium
go.drugbank.com/drugs/DB01370ApprovedInvestigationalWithdrawnA metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.