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Dabrafenib
go.drugbank.com/drugs/DB08912ApprovedInvestigationalDabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic n...
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP2B6 InducersAfatinib
go.drugbank.com/drugs/DB08916ApprovedInvestigationalAfatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for pat...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesAliskiren
go.drugbank.com/drugs/DB09026ApprovedInvestigationalAliskiren is the first drug in the renin inhibitor drug class and is used for the treatment of hypertension. It was developed by Speedel and Novartis and initially approved by the FDA in early 2007. Aliskiren has been proven to efficacio...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesEliglustat
go.drugbank.com/drugs/DB09039ApprovedInvestigationalEliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease. Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glu...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesTedizolid phosphate
go.drugbank.com/drugs/DB09042ApprovedDrug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus penumoniae, represent a massive public health threat. Tedizolid is a member o...
Cannabidiol
go.drugbank.com/drugs/DB09061ApprovedInvestigationalCannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological ...
Synonyms: (−)-trans-2-p-mentha-1,8-dien-3-yl-5-pentylresorcinolCategories: P-glycoprotein inhibitors, Cytochrome P-450 CYP1A2 InducersPalbociclib
go.drugbank.com/drugs/DB09073ApprovedInvestigationalPalbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmac...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesTrimebutine
go.drugbank.com/drugs/DB09089ApprovedInvestigationalTrimebutine is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects. It is marketed for the treatment of irritable bowel syndrome (IBS) and ...
International brands: NeptenCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesZucapsaicin
go.drugbank.com/drugs/DB09120ApprovedWithdrawnZucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is a modulator of transient receptor potential cation channel subfamily V member 1 (TRPV-1), also kn...
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2C19 InhibitorsDasabuvir
go.drugbank.com/drugs/DB09183ApprovedDasabuvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is ...
Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates