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Displaying results 3161 - 3170 of 3180 in total

Drug
Biricodar
go.drugbank.com/drugs/DB04851
Investigational
The pipecolinate derivative biricodar (VX-710) is a clinically applicable modulator of P-glycoprotein (Pgp) and multidrug resistance protein (MRP-1).
Categories: P-glycoprotein inhibitors
Drug
Nilotinib
go.drugbank.com/drugs/DB04868
ApprovedInvestigational
Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered si...
Categories: P-glycoprotein inhibitors, P-glycoprotein substrates
Drug
Flibanserin
go.drugbank.com/drugs/DB04908
ApprovedInvestigational
Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. In February of 2018 Flibanserin was approved by Health Canada under the brand name Addyi for a si...
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitors
Drug
Clevidipine
go.drugbank.com/drugs/DB04920
ApprovedInvestigational
Clevidipine is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not an option.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inducers
Drug
Indacaterol
go.drugbank.com/drugs/DB05039
ApprovedInvestigational
Indacaterol is a novel, ultra-long-acting, rapid onset β(2)-adrenoceptor agonist developed for Novartis for the once-daily management of asthma and chronic obstructive pulmonary disease. It was approved by the European Medicines Agency (...
Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
Drug
Telmapitant
go.drugbank.com/drugs/DB20768
Experimental
The usage of the INN stem '-pitant' in the name indicates that Telmapitant is a neurokinin NK1 (substance P) receptor antagonist. Telmapitant has a monoisotopic molecular weight of 515.16 Da.
Drug
Taltobulin
go.drugbank.com/drugs/DB20832
Experimental
Taltobulin is a small molecule drug. Taltobulin has a monoisotopic molecular weight of 473.33 Da.
Categories: P-glycoprotein substrates
Drug
Tabimorelin
go.drugbank.com/drugs/DB20892
Experimental
Tabimorelin is a small molecule drug. The usage of the INN stem '-relin' in the name indicates that Tabimorelin is a pituitary hormone-release stimulating peptide. Tabimorelin has a monoisotopic molecular weight of 528.31 Da.
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 Inhibitors
Drug
Perbufylline
go.drugbank.com/drugs/DB20935
Experimental
The usage of the INN stem '-fylline' in the name indicates that Perbufylline is a N-methylated xanthine derivative. Perbufylline has a monoisotopic molecular weight of 441.22 Da.
Drug
Dapitant
go.drugbank.com/drugs/DB20991
Experimental
The usage of the INN stem '-pitant' in the name indicates that Dapitant is a neurokinin NK1 (substance P) receptor antagonist. Dapitant has a monoisotopic molecular weight of 561.29 Da.