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Displaying results 311 - 320 of 9431 in total
  1. Drug

    Rinucumab

    go.drugbank.com/drugs/DB16313
    Investigational

    Rinucumab is under investigation in clinical trial NCT02418754 (Study of Intravitreal REGN2176-3 in Participants With Neovascular ("Wet") Age-related Macular Degeneration (AMD)).

    Synonyms: Immunoglobulin g4, anti-(human platelet-derived growth factor receptor~) (human monoclonal regn2176 heavy chain), disulfide with human monoclonal regn2176 k-chain, dimer
  2. Drug

    Belrestotug

    go.drugbank.com/drugs/DB19066
    Investigational

    Belrestotug is under investigation in clinical trial NCT05565378 (A Platform Study of Novel Immunotherapy Combinations in Participants With Previously Untreated, Advanced/metastatic Non-small-cell Lung Cancer).

    Synonyms: Immunoglobulin g1, anti-(human receptor tigit) (human monoclonal eos884448 .gamma.1-chain), disulfide with human monoclonal eos884448 .kappa.-chain, dimer
  3. Drug

    Pacanalotamab

    go.drugbank.com/drugs/DB17254
    Investigational

    Synonyms: Bispecific t-cell engager antibody with a single chain fc moiety that binds to b cell maturation antigen surface receptor and cd3
  4. Drug

    Tramadol

    go.drugbank.com/drugs/DB00193
    ApprovedInvestigational

    into active metabolites: (+)-tramadol and its primary metabolite (+)-O-desmethyl-tramadol (M1) are agonists of the μ opioid receptor while (+)-tramadol inhibits serotonin reuptake and (-)-tramadol inhibits … These pathways are complementary and synergistic, improving tramadol's ability to modulate the perception of and response to pain.

    Mixtures: STADIUM-T, TRALIC TPCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, NMDA Receptor Antagonists
  5. Drug

    Receptor binding domain (RBD) SARS-CoV-2 (COVID-19) hepatitis B surface antigen (HBsAg) virus-like particle (VLP) vaccine

    go.drugbank.com/drugs/DB16431
    Experimental

    Regarding this vaccine specifically, it stimulates the immune system to produce anti-receptor binding domain antibodies[A226593]. … to the hepatitis B surface antigen[A226593].

  6. Drug

    Clopidogrel

    go.drugbank.com/drugs/DB00758
    ApprovedInvestigational

    in recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and … Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.

    Mixtures: CLOPIDOGREL E ACIDO ACETILSALICILICO VIATRIS, CLOPIDOGREL E ACIDO ACETILSALICILICO VIATRISCategories: Purinergic P2 Receptor Antagonists, Purinergic P2Y Receptor Antagonists
  7. Drug

    Obecabtagene autoleucel

    go.drugbank.com/drugs/DB17362
    ApprovedInvestigational

    Obecabtagene autoleucel is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy with a fast off-rate binding profile for CD19. … [A265050] On November 8, 2024, obecabtagene autoleucel was approved by the FDA for the treatment of relapsed or refractory B-cell precursor acute lymphoblastic leukemia.

    Categories: Genetically-modified Autologous T Cells, CD19-Directed Genetically Modified Autologous T-cell ImmunotherapiesSynonyms: A CHIMERIC ANTIGEN RECEPTOR (CAR) CONSISTING O, SELF-INACTIVATING LENTIVIRAL VECTOR CONSISTING OF 5' FUSION BETWEEN THE CMV PROMOTER AND HIV LTR, WHERE THE CMV PROMOTER REPLACES THE U3 REGION.
  8. Drug

    Netarsudil

    go.drugbank.com/drugs/DB13931
    ApprovedInvestigational

    solution) 0.02% for the indication of reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. … humour outflow to act as an inhibitor to the rho kinase and norepinephrine transporters found there as opposed to affecting protaglandin F2-alpha analog like mechanisms in the unconventional uveoscleral

  9. Drug

    DF-1001

    go.drugbank.com/drugs/DB18231
    Investigational

    Synonyms: Heterodimeric multi-specific IgG1 antibody targeting human epidermal growth factor receptor 2 (HER2) and NKG2D on natural killer (NK) and cytotoxic T-cells
  10. Drug

    Barecetamab

    go.drugbank.com/drugs/DB17479
    Investigational

    Synonyms: Immunoglobulin g1, anti-(human epidermal growth factor receptor her3) (human monoclonal isu104 .gamma.1-chain), disulfide with human monoclonal isu104 .lambda.-chain, dimer