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Digitoxin
go.drugbank.com/drugs/DB01396ApprovedWithdrawnA cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: Digimerck 0,1 mg/ml - Injektionslösung, Digimerck 0,07 mg - TablettenMethyldopa
go.drugbank.com/drugs/DB00968ApprovedInvestigational[A1499] Methyldopa exists in two isomers D-α-methyldopa and L-α-methyldopa, which is the active form. … Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent.
Mixtures: Aldoril 15 Tab, Apo Methazide 15Categories: Amino Acids, Peptides, and Proteins, Adrenergic alpha-2 Receptor AgonistsAsunaprevir
go.drugbank.com/drugs/DB11586ApprovedWithdrawn[A32528] It was developed by Bristol-Myers Squibb Canada and approved by Health Canada on April 22, 2016. The commercialization of asunaprevir was cancelled one year later on October 16, 2017.[L1113] … It has been shown to have a very high efficacy in dual-combination regimens with daclatasvir in patients chronically infected with HCV genotype 1b.
Categories: daclatasvir, asunaprevir and beclabuvir, P-glycoprotein inhibitorsProducts: SUNVEPRA 100 MG KAPSÜL, 56 ADET, SUNVEPRA® 100MG CÁPSULAS BLANDASIsavuconazole
go.drugbank.com/drugs/DB11633ApprovedInvestigationalIt is proposed that the intravenous and oral dosing can be used interchangeably [L1482], without the need for a repeat loading dose when transitioning from an IV to an oral formulation [A32026]. … intravenous formulation is cyclodextrin-free which gives isavuconazole an advantage over other azole antifungals that requires cyclodextrin for facilitating drug solubility; this is because cyclodextrin has a
Categories: Heterocyclic Compounds, 1-Ring, Isavuconazole and ProdrugsProducts: CRESEMBA (100 MG HARD CAPSULES), CRESEMBA (POWDER FOR SOLUTION FOR CONCENTRATE FOR SOLUTION FOR INFUSION 200 MG/VIAL)Isoconazole
go.drugbank.com/drugs/DB08943ApprovedIsoconazole is an azole antifungal drug that has similar effectiveness to clotrimazole in the treatment of foot and vaginal infections.
Mixtures: TİNAGEN 1 MG+10 MG/1 G DERİ KREMİ, 15 G, TRODERM 10 MG/G+1 MG/G KREM ,15 GCategories: Heterocyclic Compounds, 1-Ring, Imidazole and Triazole DerivativesDornase alfa
go.drugbank.com/drugs/DB00003ApprovedInvestigationalDornase alfa cleaves extracellular DNA to 5´-phosphodinucleotide and 5´-phosphooligonucleotide end products without affecting intracellular DNA. … Dornase alfa is a biosynthetic form of human deoxyribunuclease I (DNase I) enzyme. It is produced in genetically modified Chinese hamster ovary (CHO) cells using recombinant DNA technology.
Synonyms: Deoxyribonuclease (human clone 18-1 protein moiety)Categories: Recombinant Human Deoxyribonuclease 1, Enzymes and CoenzymesDexrazoxane
go.drugbank.com/drugs/DB00380ApprovedInvestigationalWithdrawnIt appears to inhibit formation of a toxic iron-anthracycline complex. … [PubChem] The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the prevention or reduction in the incidence and severity of anthracycline-induced cardiomyopathy.
Synonyms: (+)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane, 2,6-Piperazinedione, 4, 4'-(1-methyl-1,2-ethanediyl)bis-, (S)- (9CI)Categories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingVerteporfin
go.drugbank.com/drugs/DB00460ApprovedInvestigationalVerteporfin, marketed as Visudyne, is a benzoporphyrin derivative comprising a 50:50 mixture of two isomers: [CL-315555] and [CL-315585]. … oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds with 4 or More RingsProducts: VISUDYNE FOR INJECTION 15 mg/vial, VISUDYNE 15 MG INFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN TOZAnifrolumab
go.drugbank.com/drugs/DB11976ApprovedInvestigational[A237079,L34929] Three monoclonal antibodies (anifrolumab, [rontalizumab], and [sifalimumab]) that target the type 1 interferon pathway entered clinical trials as potential treatments for systemic lupus … Anifrolumab, or MEDI-546, is a type 1 interferon receptor (IFNAR) inhibiting IgG1κ monoclonal antibody indicated in the treatment of adults with moderate to severe systemic lupus erythematosus.
Categories: Type I Interferon Receptor Antagonist, Amino Acids, Peptides, and ProteinsProducts: Saphnelo 300 mg/2 mL İnfüzyonluk Çözelti Hazırlamak İçin Konsantre, 1 ADETHexamidine
go.drugbank.com/drugs/DB03808ApprovedInvestigationalMixtures: Imazol duo 10 mg/g + 2,5 mg/g CremeCategories: Biguanides and Amidines, Antiseptics and Disinfectants