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OPB-111077
go.drugbank.com/drugs/DB16630InvestigationalIt has demonstrated promising anticancer activity in preclinical models.
Emprumapimod
go.drugbank.com/drugs/DB17603InvestigationalIt was investigated for dilated cardiomyopathy.
AMB-301
go.drugbank.com/drugs/DB18094Experimental[L48101] It is under investigation for the treatment of Buerger disease.
Aptazapine
go.drugbank.com/drugs/DB09305ExperimentalAlthough Aptazapine reached clinical trials, it was never marketed. … It antagonised α2 adrenergic receptors approximately 10 times more effectively than mianserin, antagonised 5-HT2 receptors, agonised H1 receptors, and did not affect reuptake of serotonin or norepinephrine
Desmethylprodine
go.drugbank.com/drugs/DB01478ExperimentalIllicitIt has been listed as a Schedule I controlled drug in the United States, and thus is not used clinically. It is known to be a designer drug, synthesized in 1977, for the purpose of recreational use.
KB002
go.drugbank.com/drugs/DB05194ExperimentalIt is developed for the treatment of autoimmune diseases, initially rheumatoid arthritis.