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WX-UK1
go.drugbank.com/drugs/DB05476InvestigationalIn animal models, WX-UK1 blocks tumor cell invasion, metastasis and primary tumor growth by inhibiting serine proteases and the urokinase Plasminogen Activator (uPA) system, which have been shown to play … WX-UK1 is a 3-amidinophenylalanine-based non-cytotoxic small molecule that belongs to a new class of drugs.
Gedatolisib
go.drugbank.com/drugs/DB11896ApprovedInvestigational[L63927] Gedatolisib was approved by the FDA on July 14, 2026, in combination with [fulvestrant], with or without [palbociclib], for adults with HR-positive, HER2-negative locally advanced or metastatic … [L63927] Its approval also addresses a population defined by the absence of a biomarker, as patients with PIK3CA wild-type disease were not eligible for the PI3Kα-selective options.
Hydroxyethyl cellulose
go.drugbank.com/drugs/DB11602ApprovedHydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmet...
Categories: Compounds used in a research, industrial, or household settingSolenopsis richteri
go.drugbank.com/drugs/DB11026ApprovedIt is extracted from the black imported fire ant which is native to South Amercia. The species has also been introduced in North Amercia. … When stung, the bites are characterized by sterile pustules that are surrounded by reddened swelling along with redness extending beyond.
Zolazepam
go.drugbank.com/drugs/DB11555ExperimentalVet approvedIt is around four times the potency of diazepam but it is both water-soluble and un-ionized at physiological pH meaning that its onset is very fast. … Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine.
Mazindol
go.drugbank.com/drugs/DB00579ApprovedMazindol is only approved in the United States for the treatment of Duchenne muscular dystrophy, and is not marketed or available in the United States for use in the treatment of obesity. … Mazindol is a tricyclic anorexigenic agent that is unrelated to and less toxic than [amphetamine], but with some similar side effects.
Bexotegrast
go.drugbank.com/drugs/DB16515InvestigationalThe compound was granted orphan drug designation by the US FDA in August 2018 for treatment of IPF, and Pliant Therapeutics recently raised $100 million in Series C financing to support further clinical … Phase 2a studies are currently evaluating PLN-74809 safety and efficacy for participants with IPF (NCT04396756)across 10 participating countries[L31703], and for participants with PSC (NCT04480840).
Categories: Experimental Unapproved Treatments for COVID-19Motixafortide
go.drugbank.com/drugs/DB14939ApprovedInvestigational[A261476] Motixafortide was approved by the FDA in September 2023, in combination with filgrastim, for use in stem cell mobilization prior to autologous stem cell transplant in patients with multiple … [L48141] It has also been investigated alongside [pembrolizumab] for the treatment of pancreatic cancer.[A261481]
Phenprocoumon
go.drugbank.com/drugs/DB00946ApprovedInvestigationalWithdrawnCoumarin derivative that acts as a long-acting oral anticoagulant.
Categories: Vitamin K Inhibitors, Vitamin K AntagonistsEcallantide
go.drugbank.com/drugs/DB05311ApprovedEcallantide is marketed by FDA and EMA under the trade name Kalbitor for subcutaneous injection. … Apart from its FDA and EMA indication, ecallantide has been used off label in the management of nonhistaminergic angioedema, not due to HAE [A32017].