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Tesmilifene
go.drugbank.com/drugs/DB04905InvestigationalTesmilifene is a novel potentiator of chemotherapy which, when added to doxorubicin, achieved an unexpected and very large survival advantage over doxorubicin alone in a randomized trial in advanced breast
Categories: P-glycoprotein inducers, P-glycoprotein inhibitorsSynonyms: N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamineAfamelanotide
go.drugbank.com/drugs/DB04931ApprovedAfamelanotide is a first-in-class, synthetic, 13-amino acid peptide analogue of the endogenous alpha melanocyte-stimulating hormone (α-MSH). … [L9086] It differs structurally from its endogenous counterpart by only two amino acids - these structural differences improve biological efficacy by imparting a greater affinity for its target and a longer
Categories: Melanocortin 1 Receptor (MC1-R) Agonists, Compounds used in a research, industrial, or household settingSynonyms: MT-I, Melanotan 1Eritoran
go.drugbank.com/drugs/DB04933InvestigationalEritoran is a structural analogue of the lipid A portion of lipopolysaccharide (LPS). It is being developed by Eisai Research Institute of Boston for the treatment of severe sepsis.
Categories: Toll-Like Receptor 4, antagonists & inhibitorsAzimilide
go.drugbank.com/drugs/DB04957InvestigationalAzimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of the delayed rectifier cardiac potassium channels. It is not approved for use in any country, but is currently in clinical trials in th...
Synonyms: 1-((5-(P-CHLOROPHENYL)FURFURYLIDENE)AMINO)-3-(4-(4-METHYL-1-PIPERAZINYL)BUTYL)HYDANTOIN, 2,4-IMIDAZOLIDINEDIONE, 1-(((5-(4-CHLOROPHENYL)-2-FURANYL)METHYLENE)AMINO)-3-(4-(4-METHYL-1-PIPERAZINYL)BUTYL)-Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingElafibranor
go.drugbank.com/drugs/DB05187ApprovedInvestigationalElafibranor is a dual peroxisome proliferator-activated receptor (PPAR) α and β/δ agonist [A263833] that works to inhibit bile acid synthesis.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersSynonyms: PROPANOIC ACID, 2-(2,6-DIMETHYL-4-((1E)-3-(4-(METHYLTHIO)PHENYL)-3-OXO-1-PROPEN-1-YL)PHENOXY)-, PROPANOIC ACID, 2-(2,6-DIMETHYL-4-(3-(4-(METHYLTHIO)PHENYL)-3-OXO-1-PROPEN-1-YL)PHENOXY)-2-METHYL-Beraprost
go.drugbank.com/drugs/DB05229InvestigationalBeraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary hypertension. It is also being studied for use in avoiding reperfusion injury.
Categories: Prostaglandins I, Cytochrome P-450 SubstratesProducts: ดอร์เนอ(R) ชนิดเม็ด 20 ไมโครกรัมRotigotine
go.drugbank.com/drugs/DB05271ApprovedInvestigationalIt is formulated as a once-daily transdermal patch which provides a slow and constant supply of the drug over the course of 24 hours. … Rotigotine has been authorized as a treatment for RLS since August 2008.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSynonyms: (6S)-6-(propyl(2-(2-thienyl)ethyl)amino)-5,6,7,8-tetrahydro-1-naphthalenolHistamine
go.drugbank.com/drugs/DB05381ApprovedInvestigationalIt is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. … A depressor amine derived by enzymatic decarboxylation of histidine.
Mixtures: Histamine DHCl 0.10 Percent and Menthol 2 PercentCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP3A InhibitorsCanertinib
go.drugbank.com/drugs/DB05424InvestigationalCanertinib is a pan-erbB tyrosine kinase inhibitor which work against esophageal squamous cell carcinoma in vitro and in vivo.
Categories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingBudiodarone
go.drugbank.com/drugs/DB05519InvestigationalBudiodarone (ATI-2042) is an antiarrhythmic related to amiodarone that is currently being studied in clinical trials.
Categories: Heterocyclic Compounds, 2-Ring