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Displaying results 3641 - 3650 of 10000 in total
  1. Drug

    AVI-5126

    go.drugbank.com/drugs/DB05726
    Investigational

    AVI-526 works by silencing a gene known as c-myc, a key regulatory gene involved in cardiovascular restenosis. … AVI-526 is an improved formulation of [AVI-4557], developed for use on Vein Grafts before use in Heart by-Pass Graft Surgery.

  2. Drug

    Bufogenin

    go.drugbank.com/drugs/DB19835
    Experimental

    Bufogenin is a small molecule drug. Bufogenin has a monoisotopic molecular weight of 384.23 Da.

    Categories: Compounds used in a research, industrial, or household setting
  3. Drug

    Tozuleristide

    go.drugbank.com/drugs/DB15375
    Investigational

    Tozuleristide is under investigation in clinical trial NCT02464332 (Safety Study of BLZ-100 in Adult Subjects With Sarcoma Undergoing Surgery).

    Synonyms: N6.27-(6-(2-(7-(1,1-DIMETHYL-3-(4-SULFONATOBUTYL)-1H-BENZO(E)INDOL-1-IUM-2-YL)HEPTA-2,4,6-TRIENYLIDENE)-1,1-DIMETHYL-1,2-DIHYDRO-3H-BENZO(E)INDOL-3-YL)HEXANOYL)(15-ARGININE(K>R),23-ARGININE(K>R))CHLOROTOXINCategories: Compounds used in a research, industrial, or household setting
  4. Drug

    Lovotibeglogene autotemcel

    go.drugbank.com/drugs/DB18680
    ApprovedInvestigational

    [A262736,L49256] On December 8, 2023, lovotibeglogene autotemcel was approved by the FDA under the brand name Lyfgenia for the treatment of sickle cell disease (SCD) in patients ages 12 and older who … have a history of vaso-occlusive events.

  5. Drug

    MBO7133

    go.drugbank.com/drugs/DB04999
    Experimental

    MB07133 is a HepDirect prodrug of an activated form of cytarabine (araC), an anti-cancer drug that is used to treat leukemia but is ineffective against primary liver cancer. … MB07133 uses our HepDirect technology to target a prodrug form of araCMP specifically to the liver.

  6. Drug

    Proscillaridin

    go.drugbank.com/drugs/DB13307
    Experimental

    Proscillaridin is a cardiac glycoside that is derived from plants of the genus Scilla and in Drimia maritima (Scilla maritima). … Studies suggest the potential cytotoxic and anticancer property of proscillaridin, based on evidence of the drug potently disrupting topoisomerase I and II activity at nanomolar drug concentrations [A27193

    Categories: Compounds used in a research, industrial, or household setting
  7. Drug

    Fluoroazomycin arabinoside F-18

    go.drugbank.com/drugs/DB15134
    Investigational

    Fluoroazomycin arabinoside F-18 is under investigation in clinical trial NCT03257150 (A Study of the Use of Irreversible Electroporation in Pancreatic Ductal Cancer).

    Categories: Compounds used in a research, industrial, or household setting
  8. Drug

    Ibudilast

    go.drugbank.com/drugs/DB05266
    Investigational

    Ibudilast is currently in development in the U.S. (codes: AV-411 or MN-166), but is approved for use as an antiinflammatory in Japan. … Ibudilast is an anti-inflammatory and neuroprotective oral agent which shows an excellent safety profile at 60 mg/day and provides significantly prolonged time-to-first relapse and attenuated brain volume

  9. Drug

    OXI-4503

    go.drugbank.com/drugs/DB05143
    Investigational

    OXI-4503 is investigated in clinical trials for treating cancer/tumors. OXI-4503 is a solid. OXI-4503 blocks and destroys tumor vasculature, resulting in extensive tumor cell death and necrosis. … Preclinical studies have demonstrated that OXI-4503 has (i) single-agent activity against a range of xenograft tumor models; and (ii) synergistic or additive effects when incorporated in various combination

    Synonyms: Combretastatin A-1 bis(phosphate)
  10. Drug

    Sitamaquine

    go.drugbank.com/drugs/DB04909
    Investigational

    Sitamaquine (WR-6026) is an orally active 8-aminoquinoline analog in development by the Walter Reed Army Institute, in collaboration with GlaxoSmithKline (formerly SmithKline Beecham), for the potential