Search

Displaying results 411 - 420 of 10000 in total
  1. Drug

    Exagamglogene autotemcel

    go.drugbank.com/drugs/DB15572
    ApprovedInvestigational

    Sickle cell disease (SCD) is a genetic disorder characterized by the production of abnormal sickle-shaped red blood cells (called hemoglobin S, HbS) that initiate a pathophysiology resulting in severe … [L10139] Following engraftment, it causes an increase in the production of HbF and a subsequent decrease in HbS.

    Synonyms: gene editing consisting of a guide RNA (gRNA), Autologous CD34+ cells isolated from mobilised peripheral blood by positive selection, modified by CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) mediated
  2. Drug

    Obecabtagene autoleucel

    go.drugbank.com/drugs/DB17362
    ApprovedInvestigational

    Obecabtagene autoleucel is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy with a fast off-rate binding profile for CD19. … [A265040,A265045] It works by targeting B-cell-specific CD19 surface markers present on malignant B cells.

    Categories: Genetically-modified Autologous T Cells, CD19-Directed Genetically Modified Autologous T-cell ImmunotherapiesSynonyms: A CHIMERIC ANTIGEN RECEPTOR (CAR) CONSISTING O, AUTOLOGOUS CD4+ AND CD8+ T CELLS, ENRICHED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMCS) OBTAINED BY APHERESIS TRANSDUCED EX VIVO WITH A NON-REPLICATING, SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR, ENCODING
  3. Drug

    OXI-4503

    go.drugbank.com/drugs/DB05143
    Investigational

    OXI-4503 (combretastatin A1 di-phosphate / CA1P) is a unique and highly potent, dual-mechanism vascular disrupting agent (VDA). … OXI-4503 is a solid. OXI-4503 blocks and destroys tumor vasculature, resulting in extensive tumor cell death and necrosis.

    Synonyms: Combretastatin A-1 bis(phosphate), Combretastatin A1 diphosphate
  4. Drug

    Gildeuretinol

    go.drugbank.com/drugs/DB18468
    Investigational

    Synonyms: VITAMIN A ACETATE C20-D3
  5. Drug

    (R)-3-hydroxydecanoyl-CoA

    go.drugbank.com/drugs/DB03192
    Experimental

    Synonyms: (R)-3-hydroxydecanoyl-coenzyme A, (R)-3-hydroxydecanoyl-CoA
  6. Drug

    3'-O-N-Octanoyl-a-D-Glucopyranosyl-B-D-Fructofuranoside

    go.drugbank.com/drugs/DB02346
    Experimental

    Synonyms: 3'-O-N-Octanoyl-a-D-Glucopyranosyl-B-D-Fructofuranoside
  7. Drug

    1,3,4-TRIHYDROXY-5-(3-PHENOXYPROPYL)-CYCLOHEXANE-1-CARBOXYLIC A CID

    go.drugbank.com/drugs/DB04656
    Experimental

    Synonyms: 1,3,4-TRIHYDROXY-5-(3-PHENOXYPROPYL)-CYCLOHEXANE-1-CARBOXYLIC A CID
  8. Drug

    N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine

    go.drugbank.com/drugs/DB08056
    Experimental

    Synonyms: N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine
  9. Drug

    1,3-DI(N-Propyloxy-A-mannopyranosyl)-carbomyl 5-methyazido-benzene

    go.drugbank.com/drugs/DB03634
    Experimental

    Synonyms: 1,3-DI(N-Propyloxy-A-mannopyranosyl)-carbomyl 5-methyazido-benzene
  10. Drug

    Bambermycins

    go.drugbank.com/drugs/DB11377
    ExperimentalVet approved

    They are used as an additive in food ingested by chickens and swine. The bambermycin complex of antibiotics consists primarily of moenomycins A and C.

    Synonyms: Moenomycin A