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Probucol
go.drugbank.com/drugs/DB01599ApprovedInvestigationalWithdrawnA drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
Oxyquinoline
go.drugbank.com/drugs/DB11145ApprovedInvestigationalVet approvedOxyquinoline is a heterocyclic phenol and derivative of quinoline with antiseptic, disinfectant, and pesticide properties. It is used as a stabilizer for hydrogen peroxide, where it is sometimes added in cosmetic products.
Mixtures: Fem pHFondaparinux
go.drugbank.com/drugs/DB00569ApprovedInvestigationalknee surgery); to prevent VTE in patients undergoing abdominal surgery who are are at high risk of thromboembolic complications; in the treatment of deep vein thrombosis (DVT) and pumonary embolism (PE
Nirmatrelvir
go.drugbank.com/drugs/DB16691ApprovedInvestigational[A234224,A234229,A234234] In 2020, Pfizer was investigating another potential treatment for SARS-CoV-2, [PF-07304814]. … Nirmatrelvir (PF-07321332) is an orally bioavailable 3C-like protease (3CL<sup>PRO</sup>) inhibitor that is the subject of clinical trial NCT04756531.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesTramadol
go.drugbank.com/drugs/DB00193ApprovedInvestigationalproperty through different mechanisms and are also themselves metabolized into active metabolites: (+)-tramadol and its primary metabolite (+)-O-desmethyl-tramadol (M1) are agonists of the μ opioid receptor
Mixtures: DUODUET - PT, AUROMYOTRAM-P ® TABLETASCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesHyoscyamine
go.drugbank.com/drugs/DB00424ApprovedInvestigationalHyoscyamine is a tropane alkaloid and the levo-isomer of atropine. It is commonly extracted from plants in the Solanaceae or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyami...
Mixtures: Uta, UtaMomelotinib
go.drugbank.com/drugs/DB11763ApprovedInvestigationalMF includes primary MF (PMF), post-polycythemia vera (PV) MF, and post-essential thrombocythemia (ET) MF. Clinical manifestations of MF include anemia and thrombocytosis.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesPioglitazone
go.drugbank.com/drugs/DB01132ApprovedInvestigationalclass of medications, which also includes [rosiglitazone] and [troglitazone], exerts its pharmacological effect primarily by promoting insulin sensitivity and the improved uptake of blood glucose[L11416] via … [A19759] Thiazolidinediones, including pioglitazone, have fallen out of favor in recent years due to the presence of multiple adverse effects and warnings regarding their use (e.g. congestive heart
Mixtures: INCRESINA PCategories: Peroxisome Proliferator Receptor gamma Agonist, Peroxisome Proliferator-activated Receptor ActivityPretomanid
go.drugbank.com/drugs/DB05154ApprovedInvestigationalResearch in recent years has been geared toward the development of novel therapies that target persistent forms of this disease, which have shown resistance to standard therapy regimens.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesDonepezil
go.drugbank.com/drugs/DB00843ApprovedInvestigationalIn 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholineste...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates