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Displaying results 4471 - 4480 of 10000 in total
  1. Drug

    Adakitug

    go.drugbank.com/drugs/DB05484
    Investigational

    In pre-clinical studies, HuMax-Inflam has been shown to inhibit tumor growth in tumor models using primary human tumors in immunodeficient mice. … MDX-018, also known as HuMax-Inflam, is a fully human antibody that is directed to IL-8 (interleukin-8) and may have potential application in oncology and inflammation.

    Synonyms: HuMax IL-8, HuMax-IL-8
  2. Drug

    Inositol 1,3-bisphosphate

    go.drugbank.com/drugs/DB02942
    Experimental

    The compound corresponds to the soluble headgroup of phosphatidylinositol 3-phosphate (PtdIns(3)P), an endosomal signaling lipid recognized by FYVE domains, and it has been used as a ligand in structural … Inositol 1,3-bisphosphate is a phosphorylated myo-inositol derivative and small molecule metabolite in which phosphate groups occupy the 1 and 3 positions of the inositol ring.

  3. Drug

    Polymyxin B

    go.drugbank.com/drugs/DB00781
    ApprovedInvestigationalVet approved

    Polymyxin B has a narrow therapeutic index and so its use is limited and unlikely to be used first line[A176429]. … Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label].

    Synonyms: Polymyxin B, Polimixina BInternational brands: Polomyxin B
  4. Drug

    Tegoprazan

    go.drugbank.com/drugs/DB16690
    Investigational

    [A234220] It has also been observed to be efficacious independent of food intake.[A234220] … [A234215, A234220] This drug is a potent and high-selective potassium-competitive acid blocker (P-CAB) with a fast onset of action and the ability to control gastric pH for a prolonged period of time.

    Synonyms: K-CABCategories: Heterocyclic Compounds, 1-Ring
  5. Drug

    Rocatinlimab

    go.drugbank.com/drugs/DB18809
    Investigational

    The drug works by targeting the OX40 receptor, which plays a role in the immune response associated with atopic dermatitis. … In clinical trials, it has shown significant efficacy and safety compared to a placebo.

  6. Drug

    NNZ-2591

    go.drugbank.com/drugs/DB15601
    Investigational

    NNZ-2591 (cyclo-L-glycyl-L-2-allylproline)[A189390] is an investigational synthetic analog of cyclic glycine-proline (cGP), a breakdown product of human insulin-like growth factor 1 (IGF-1), that has been … It was granted Orphan Drug Designation by the FDA in October 2019[L11103] and was granted a patent by the European Patent Office in December 2019.

    Synonyms: Cyclo(-L-glycyl-L-2-allylproline), Pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-8a-(2-propenyl)-, (8aR)-Categories: Heterocyclic Compounds, 1-Ring
  7. Drug

    Fasinumab

    go.drugbank.com/drugs/DB12157
    Investigational

    Fasinumab is a human IgG1k monoclonal antibody targeted against nerve growth factor (NGF). … [A241190] It has since been recognized for its role in nociceptive signaling transduction and has thus become an attractive target in the treatment of chronic pain conditions.

  8. Drug

    MB07811

    go.drugbank.com/drugs/DB05192
    Investigational

    MB07811, a small molecule that is administered orally, has been extensively studied preclinically and is currently undergoing clinical testing. … MB07811 combines a novel thyroid hormone receptor agonist with the Company's novel HepDirect liver targeting prodrug technology.

  9. Drug

    4-Hydroxytestosterone

    go.drugbank.com/drugs/DB01485
    IllicitInvestigational

    [A14385] Like formestane, 4-hydroxytesterone has been patented for use in decreasing estrogen production in the body, but no such indication currently exists. 4-Hydroxytestosterone was first patented in … 4-Hydroxytestosterone is testosterone substituted with a hydroxy group on the fourth carbon atom.

    Synonyms: 4-Androstene-7alpha-17beta-diol-3-one, 4,17beta-Dihydroxy-4-androstene-3-one
  10. Target

    Voltage-gated inwardly rectifying potassium channel KCNH2

    go.drugbank.com/bio_entities/BE0000090
    TargetTransporterHumans

    Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed:10219239, PubMed:10753933, PubMed:10790218, PubMed:10837251, PubMed:11997281, PubMed:12063277, PubMed:18559421, PubMed:22314138, PubMed:22359612,...

    Synonyms: Ether-a-go-go-related gene potassium channel 1