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Chikungunya vaccine (live, attenuated)

[L48726] It is approved for use in patients 18 years of age and older who are at high-risk of exposure to chikungunya virus. … Chikungunya virus (CHIKV) is a member of the Alphavirus genus that was first identified in Tanzania in 1952.[A262051] It is spread primarily by the bite of infected mosquitos of the _Aedes_ genus.

Pyrrolnitrin

Fitusiran

Fitusiran is an antithrombin-directed double-stranded small interfering ribonucleic acid (siRNA) that is covalently linked to a ligand containing a triantennary N-acetylgalactosamine (GalNAc) moiety. … [L52860] Fitusiran was first approved by the FDA on March 28, 2025, as routine prophylaxis therapy to prevent or reduce the frequency of bleeding episodes associated with hemophilia A or B.

NXN-188

NXN-188 is a first-in-class, dual-action small molecule incorporating both neuronal nitric oxide synthase (nNOS) inhibition and 5-HT agonism that is being developed for the treatment of acute migraine.

PX-478

PX-478 is a small molecule inhibitor of hypoxia inducible factor (HIF)-1 alpha currently in a clinical trial in patients with advanced metastatic cancer and lymphoma.

Pirbuterol

Pirbuterol is a beta-2 adrenergic bronchodilator. … While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate that there is a population of beta-2 receptors in the human heart, existing

Liranaftate

Liranaftate is a small molecule drug. Liranaftate has a monoisotopic molecular weight of 328.12 Da.

S-8510

S-8510 / SB-737552 is a BZD inverse agonist investigated for the treatment of Alzheimer’s disease and mild to moderate senile dementia. It was being codeveloped by Shionogi and GlaxoSmithKline.

Vonoprazan

[A253702] In May 2022, the FDA approved the use of vonoprazan in a co-packaged product containing amoxicillin and clarithromycin for the treatment of _H. pylori_ infection. … [L41695] Studies have shown that the concomitant use of vonoprazan, amoxicillin, and clarithromycin leads to an _H. pylori_ eradication rate of approximately 90%.[A253742]

Chlormidazole