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Glecaprevir
go.drugbank.com/drugs/DB13879ApprovedInvestigationalIn clinical trials, this combination therapy achieved SVR12 rate, or undetectable Hepatitis C for twelve or more weeks after the end of treatment, of ≥93% across genotypes 1a, 2a, 3a, 4, 5 and 6 [L41080 … In cell cultures, the emergence of amino acid substitutions at NS3 resistance-associated positions A156 or D/Q168 in HCV genotype 1a, 2a or 3a replicons led to reduced susceptibility to glecaprevir [FDA
Categories: NS3/4A Protease Inhibitors, HCV NS3/4A Protease InhibitorsHistidine
go.drugbank.com/drugs/DB00117ApprovedInvestigationalNutraceuticalAn essential amino acid that is required for the production of histamine.
Mixtures: AA-Ven, Quick Mix 2.5% Travasol Aa With Electrolytes With 25% Dextrose InjecSynonyms: L-Histidin, L-HistidineLamivudine
go.drugbank.com/drugs/DB00709ApprovedInvestigationalA reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring.
Synonyms: beta-L-2',3'-Dideoxy-3'-thiacytidine, beta-L-3'-Thia-2',3'-dideoxycytidineMixtures: ALTAIR-PRO, LAMIVUDIN/ZID PUR 150/300Oxycodone
go.drugbank.com/drugs/DB00497ApprovedIllicitInvestigationalOxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. … for an extended period.
Mixtures: OXYCODON/NALOX PUR 10/5MG, OXYCODON/NALOX PUR 10/5MGCategories: Heterocyclic Compounds with 4 or More RingsPolymyxin B
go.drugbank.com/drugs/DB00781ApprovedInvestigationalVet approvedPolymyxin B has a narrow therapeutic index and so its use is limited and unlikely to be used first line[A176429]. … Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label].
Mixtures: Pomada De La Campana Triple Antibiotic Pain Relief, Tribioticlc Lc LcCategories: Pore Forming Cytotoxic Proteins, Antibacterials for Systemic UseTebentafusp
go.drugbank.com/drugs/DB15283ApprovedInvestigational[A244815,A244910] Uveal melanoma is a rare ocular tumour with often poor prognosis and limited treatment options. … [A244815] On January 26, 2022, tebentafusp was first approved by the FDA for the treatment of HLA-A*02:01-positive adults with unresectable or metastatic uveal melanoma.
Categories: Bispecific gp100 Peptide-HLA-directed CD3 T Cell EngagerPoor or intermediate risk Advanced Renal Cell Carcinoma (aRCC)
go.drugbank.com/conditions/DBCOND0147009Drugs: IpilimumabSynonyms: Poor or intermediate risk Advanced Renal Cell Carcinoma (aRCC)Pantothenic acid
go.drugbank.com/drugs/DB01783ApprovedInvestigationalNutraceuticalVet approvedPantothenic acid, also called pantothenate or vitamin B5 (a B vitamin), is a water-soluble vitamin discovered by Roger J. Williams in 1919. … For many animals, pantothenic acid is an essential nutrient as it is required to synthesize coenzyme-A (CoA), as well as to synthesize and metabolize proteins, carbohydrates, and fats.
Mixtures: Formula Lf, Formula F L WCategories: Preparations for Treatment of Wounds and UlcersVoxilaprevir
go.drugbank.com/drugs/DB12026ApprovedInvestigationalNotably, Vosevi is approved for use in patients with genotypes 1-6 who have been previously treated with an NS5A inhibitor, or patients with genotypes 1a or 3 infection and have previously been treated … Prior to Vosevi, there were no approved retreatment options for patients who have previously received, and failed, a regimen containing an NS5A inhibitor for treatment of chronic HCV infection.
Categories: NS3/4A Protease Inhibitors, HCV NS3/4A Protease InhibitorsChlorthalidone
go.drugbank.com/drugs/DB00310ApprovedInvestigationalChlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment. … heart failure when compared to [DB00722], [DB00381], or [DB00590].
Mixtures: Aa-atenidone, Aa-atenidoneCategories: Antihypertensive Agents Indicated for Hypertension