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Ramucirumab
go.drugbank.com/drugs/DB05578ApprovedInvestigationalBy binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stimulated receptor phosphorylation and downstream ligand-induced proliferation, … permeability, and migration of human endothelial cells.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: CYRAMZA CONCENTRATE FOR SOLUTION FOR INFUSION 100MG/10ML, Cyramza 100mg/10ml concentrate for solution for infusionMetoclopramide
go.drugbank.com/drugs/DB01233ApprovedInvestigationalIt is available in the oral tablet form or in solution, and can also be administered through the intravenous route.[T683] Metoclopramide was initially approved by the FDA in 1980.[A184922] … Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system.
Categories: Alimentary Tract and Metabolism, Benzamides and benzamide derivativesProducts: Reglan Tab 10mg, EMECON TABLET 10MGBetahistine
go.drugbank.com/drugs/DB06698ApprovedInvestigationalMénière's disease is a progressive disease of the inner ear characterized by vertigo, tinnitus, and hearing loss. … It has a significant impact on both the physical and social functioning of affected individuals.
Products: VASOMOTAL 24MG, BETAVERT N 24MGFinerenone
go.drugbank.com/drugs/DB16165ApprovedInvestigational[A236544] Spironolactone has low selectivity and affinity for the receptor; it dissociates quickly and can also have effects at the androgen, progesterone, and glucocorticoid receptors. … [A236544] Eplerenone is more selective and has longer lasting effects.
Products: KERENDIA FILM-COATED TABLET 20MG, KERENDIA FILM-COATED TABLET 10MGPrazosin
go.drugbank.com/drugs/DB00457ApprovedInvestigationalPrazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988.[L5828] It belongs to the class of drugs known as alpha-1 antagonists. … Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTSD) and associated nightmares.[A176618, A176621, A176624]
Categories: prazosin and diuretics, Alpha-Adrenoreceptor Antagonists and DiureticsProducts: Nu-prazo Tab 1mg, CAPSULAS DE 1MGPhenytoin
go.drugbank.com/drugs/DB00252ApprovedInvestigationalVet approved[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications … such as bipolar disorder, retina protection, and wound healing.
Mixtures: Dilantin W Phenobarbital 15mg, Dilantin W Phenobarbital 30mg CapCategories: Phenytoin and Prodrugs, Metabolic Side Effects of Drugs and SubstancesSibutramine
go.drugbank.com/drugs/DB01105ApprovedIllicitWithdrawnIn October 2010, Sibutramine was withdrawn from Canadian and U.S. markets due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease. … Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity.
Categories: Alimentary Tract and Metabolism, Serotonin and Noradrenaline Reuptake InhibitorsProducts: SIBUTRAMINA 15MG, SIBUTRAMINA 15MG CAPSULAEsmolol
go.drugbank.com/drugs/DB00187ApprovedInvestigationalWithdrawnIt works by blocking beta-adrenergic receptors in the heart, which leads to decreased force and rate of heart contractions. … Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine.
Products: Brevibloc Liq IV 250mg/ml, Brevibloc Liq IV 10mg/mlEfmoroctocog alfa
go.drugbank.com/drugs/DB11607ApprovedInvestigationalVIII, but does not contain the B-domain, which has no known biological function, and [DB13192], which is purified endogenous Factor VIII from human pooled blood and contains both A- and B-subunits. … Prophylactic treatment may dramatically improve the management of severe haemophilia A in the future by reducing joint bleeding and other hemorrhages that cause chronic pain and disability to patients
Products: ELOCTATE® 250 UI, ELOCTATE® 1000 UIRocuronium
go.drugbank.com/drugs/DB00728ApprovedInvestigationalIntroduced in 1994, rocuronium has rapid onset, and intermediate duration of action. It is commonly marketed under the trade names Zemuron and Esmeron. … It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery
Products: BROMURO DE ROCURONIO 25MG/2.5ML, ZEMUROC® 10MG/ML