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Displaying results 5661 - 5670 of 7186 in total
  1. Drug

    VY-HTT01

    go.drugbank.com/drugs/DB16999
    Investigational

    VY-HTT01 is a gene therapy designed to reduce the expression of huntingtin, thereby altering disease progression. … VY-HTT01 is comprised of an adeno-associated virus capsid (AAV1) and a proprietary transgene that harnesses the canonical RNA interference pathway to selectively knock down levels of HTT mRNA.

  2. Drug

    Vercirnon

    go.drugbank.com/drugs/DB15250
    Investigational

    Vercirnon is a novel, orally active anti-inflammatory agent that targets a chemokine receptor protein implicated in both Crohn's disease and ulcerative colitis, the two principal forms of IBD.

  3. Drug

    Delavirdine

    go.drugbank.com/drugs/DB00705
    ApprovedInvestigationalWithdrawn

    A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1.

    Synonyms: (N-[2-[4-[3-(1-methylethylamino)pyridin-2-yl]piperazin-1-yl]carbonyl-1H-indol-5-yl] methanesulfonamide), 2-(4-(5-methanesulfonamido-1H-indol-2-ylcarbonyl)-1-piperazinyl)-N-(1-methylethyl)-3-pyridinamine
  4. Drug

    KBP-COVID-19

    go.drugbank.com/drugs/DB15858
    Investigational

    As of July 2020, KBP is conducting a Phase 1/2 clinical trial to evaluate the safety and immunogenicity of KBP-COVID-19 vaccine in healthy patients (NCT04473690). … The KBP-201 COVID-19 Vaccine was developed by British American Tobacco’s (BAT) U.S. biotech subsidiary, Kentucky BioProcessing (KBP).

  5. Drug

    Clocapramine

    go.drugbank.com/drugs/DB09003
    Experimental

    In addition to psychosis, clocapramine has also been used to augment antidepressants in the treatment of anxiety and panic.

  6. Drug

    CDX-1135

    go.drugbank.com/drugs/DB17607
    Investigational

    CDX-1135, formerly TP-10, is a soluble, recombinant human Complement Receptor Type 1 (sCR1) developed by Avant Immunotherapeutics (now Celldex).

  7. Drug

    Zafiride

    go.drugbank.com/drugs/DB18371
    Investigational

    Zafiride is a human tumor necrosis factor coupled to the C terminus of CNGRCG peptide.

  8. Drug

    Uridine-5'-Diphosphate

    go.drugbank.com/drugs/DB03435
    Experimental

    A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety. [PubChem]

  9. Drug

    LIS-1

    go.drugbank.com/drugs/DB18388
    Experimental

    LIS-1 is an immunoglobulin G (IgG) polyclonal antibody that binds to human T cells.

  10. Drug

    Covax-19™

    go.drugbank.com/drugs/DB15846
    Investigational

    Covax-19™ was tested in animal studies, and shown to achieve potent antibody and T-cell responses against the COVID-19 spike protein. … As of June 2020, the vaccine is in Phase 1 trials to evaluate safety and immune responses (NCT04428073).