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Displaying results 51 - 60 of 10000 in total
  1. Drug

    Baclofen

    go.drugbank.com/drugs/DB00181
    ApprovedInvestigational

    Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients. … [A245338] Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.

    International brands: Lioresal Intrathecal, Nu-BaclofenCategories: Amino Acids, Peptides, and Proteins
  2. Drug

    Sage oil

    go.drugbank.com/drugs/DB11199
    ApprovedNutraceutical

    Essential oil has been traditionally used in medicine for the relief of pain and the treatment of inflammation and infections, as it is reported to exhibit carminative, antispasmodic, antiseptic, and astringent … The main constituents of sage oil include camphor, 1,8-cineole, α-thujone, β-thujone, borneol, and viridiflorol, which are thought to mainly produce the biological effects of sage oil.

    Categories: Non-Standardized Food Allergenic Extract, Non-Standardized Plant Allergenic ExtractSynonyms: Fema no. 3001
  3. Drug

    TSHA-101

    go.drugbank.com/drugs/DB18280
    Investigational

    Synonyms: adeno-associated viral vector serotype 9 (AAV9) carrying both HEXA and HEXB
  4. Drug

    Elapegademase

    go.drugbank.com/drugs/DB14712
    Approved

    [F1937] Elapegademase is generated in _E. coli_, developed by Leadiant Biosciences and FDA approved on October 5, 2018.[L4654,F1939] … group in alanine and lysine residues.

    Synonyms: ON N.ALPHA..1ALANINE AND N6 OF LYSINE RESIDUES WITH, (CYS74>SER,ALA245>THR)ADENOSINE DEAMINASE (BOS TAURUS, BOVINE)-(1-356)-PEPTIDE, PRODUCED IN ESCHERICHIA COLI, SUBSTITUTED ON N2 OF THE N-TERMINAL ALANYL RESIDUE (A1) AND ON N6 OF LYSYL RESIDUES (K) WITHCategories: Enzymes and Coenzymes, Amino Acids, Peptides, and Proteins
  5. Drug

    MM-111

    go.drugbank.com/drugs/DB17983
    Investigational

    MM-111 is a novel bispecific antibody fusion protein that co-targets the the epidermal growth factor family receptor tyrosine kinases, ERBB2 and ERBB3.

    Synonyms: Antibody bispecific for erbb2 and erbb3Categories: Amino Acids, Peptides, and Proteins
  6. Drug

    Atidarsagene autotemcel

    go.drugbank.com/drugs/DB17538
    ApprovedInvestigational

    [L45191] Libmeldy was granted orphan designation by the EMA in April 2007, and was issued a marketing authorization in the EU in December 2020 for the treatment of certain manifestations of metachromatic … Atidarsagene autotemcel, sold under the brand name Libmeldy, is a gene therapy comprising genetically modified autologous CD34+ enriched hematopoietic stem and progenitor cells transduced _ex vivo_ using

    Categories: Enzymes and Coenzymes, Alimentary Tract and MetabolismSynonyms: Autologous CD34+ cell enriched population that contains haematopoietic stem and progenitor cells (HSPC) transduced ex vivo using a lentiviral vector encoding the human arylsulfatase A (ARSA) gene
  7. Drug

    Radotermin

    go.drugbank.com/drugs/DB19127
    Investigational

    Radotermin is under investigation in clinical trial NCT01182337 (A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal Rhgdf-5 for the

    Synonyms: Recombinant human growth and differentiation factor-5
  8. Drug

    Romilkimab

    go.drugbank.com/drugs/DB16318
    Investigational

    Romilkimab is under investigation in clinical trial NCT02345070 (Efficacy and Safety of SAR156597 in the Treatment of Idiopathic Pulmonary Fibrosis).

    Synonyms: Bispecific antibody targeting interleukin 4 (IL-4) and interleukin 13 (IL-13)
  9. Drug

    Afamitresgene autoleucel

    go.drugbank.com/drugs/DB18592
    ApprovedInvestigational

    [L51114] MAGE-A4 is an intracellular cancer-testis antigen that is overexpressed by cancer cells in synovial sarcoma. … [L51114] On August 2, 2024, the FDA granted the accelerated approval of afamitresgene autoleucel, making it the first FDA-approved TCR gene therapy and the first gene therapy for the treatment of synovial

    Synonyms: AUTOLOGOUS CD4+ AND CD8+ T CELLS OBTAINED BY LEUKAPHERESIS, TRANSDUCED WITH AN HIV-DERIVED SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR, ENCODING AN ENHANCED-AFFINITY T CELL RECEPTOR (TCR) SPECIFIC FOR THE
  10. Drug

    Mucor circinelloides f. circinelloides

    go.drugbank.com/drugs/DB15512
    Approved

    Mucor circinelloides f. circinelloides allergenic extract is used in allergenic testing.

    Synonyms: Molds, rusts and smuts, mucor circinelloides f. circinelloidesCategories: Non-Standardized Fungal Allergenic Extract