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Donepezil
go.drugbank.com/drugs/DB00843ApprovedInvestigational[L41125] Though it does not alter the progression of Alzheimer's disease, donepezil is effective in managing the symptoms of its associated dementia.[T668] … Donepezil was first approved by the FDA in 1996, and its extended-release form was approved in combination with [Memantine] in 2014 to manage moderate and severe forms of Alzheimer's dementia.
Mixtures: EBICOMB 10 MG/20 MG EFERVESAN TABLET, 100 ADET, EBICOMB 5 MG/20 MG EFERVESAN TABLET, 100 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesOxcarbazepine
go.drugbank.com/drugs/DB00776ApprovedInvestigational[L8627,L8630,L8633] It is a structural derivative of [carbamazepine][A186101] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate in the blood … Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersSynonyms: 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamideEverolimus
go.drugbank.com/drugs/DB01590ApprovedInvestigationalIt is currently used as an immunosuppressant to prevent rejection of organ transplants. … In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsSynonyms: 40-O-(2-hydroxyethyl)-rapamycin, 42-O-(2-Hydroxyethyl)rapamycinAlendronic acid
go.drugbank.com/drugs/DB00630ApprovedInvestigationalIt functions by preventing resorption of bone[FDA Label][A959].
Synonyms: 4-amino-1-hydroxybutane-1,1-diphosphonic acid, (4-amino-1-hydroxybutylidene)bisphosphonic acidMixtures: BONMEGA 70 MG/2800 IU+1000 MG TEDAVI PAKETI, 4+24 ADET, OSVIPAC 70 MG+1000 MG/880 IU TEDAVI PAKETI, 4+24 ADETPertuzumab
go.drugbank.com/drugs/DB06366ApprovedInvestigationalIt consists of two heavy chains and two lights chains that have 448 and 214 residues respectively. … It was first approved by the FDA in 2012 for use with [docetaxel] and another HER2-targeted monoclonal antibody, [trastuzumab], in the treatment of metastatic HER2-positive breast cancer.
Mixtures: PHESGO® 1200 MG/600 MG, PHESGO® 1200 MG/600 MGCategories: Receptor, ErbB-2, antagonists & inhibitors, HER2 (Human Epidermal Growth Factor Receptor 2) inhibitorsDalfampridine
go.drugbank.com/drugs/DB06637ApprovedInvestigationalThis is the first drug that was specifically approved to help with mobility in these patients. FDA approved on January 22, 2010.
Synonyms: 4-AP, 4-AminopyridineCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 SubstratesDaratumumab
go.drugbank.com/drugs/DB09331ApprovedInvestigational[A7935] It was first described in the literature in 2010 as a monoclonal antibody that targets CD38+ multiple myeloma cells; the first of its kind. … In July 2024, it was further approved in combination with bortezomib, lenalidomide, and dexamethasone (D-VRd) for induction and consolidation therapy in newly diagnosed, transplant-eligible patients.
Products: DARZALEX 100 MG/5 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, DARZALEX 20 MG/MLIodine
go.drugbank.com/drugs/DB05382ApprovedInvestigationalIodine is commonly used as an antiseptic for minor cuts and abrasions, preventing infections that may result from contaminated wounds. … Additionally, iodine has been studied in the treatment of fibrocystic disease and breast cancer.[A3413,A192153,A192156,A192159]
Mixtures: Duet DHA 400 ec, Vitamines Et Mineraux Enfants 970Categories: Herbs and Natural ProductsChlorthalidone
go.drugbank.com/drugs/DB00310ApprovedInvestigational[A173863] In particular, the ALLHAT trial confirmed the role of thiazide diuretics as first-line therapy and demonstrated that chlorthalidone had a statistically significant lower incidence of stroke and … [A176324] Chlorthalidone is considered first-line therapy for management of uncomplicated hypertension as there is strong evidence from meta-analyses that thiazide diuretics such as chlorthalidone reduce
Mixtures: TENORETIC 100 MG/25 MG FILM TABLET, 28 ADET, Apo-Atenidone Tablets 100/25 mgCategories: Heterocyclic Compounds, 2-RingZafirlukast
go.drugbank.com/drugs/DB00549ApprovedIt is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), which is usually taken just once daily. … Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 SubstratesSynonyms: 4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-N-o-tolylsulfonylbenzamide, cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate