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Displaying results 71 - 80 of 144705 in total
  1. Drug

    GTA002

    go.drugbank.com/drugs/DB17187
    Investigational

    Synonyms: Allogeneic ex-vivo generated CD56+CD3-natural killer cells from CD34+ umbilical cord blood progenitor cells, Allogeneic UCB-NK cells
  2. Drug

    Elapegademase

    go.drugbank.com/drugs/DB14712
    Approved

    [F1937] Elapegademase is generated in _E. coli_, developed by Leadiant Biosciences and FDA approved on October 5, 2018.[L4654,F1939] … group in alanine and lysine residues.

    Categories: Enzymes and Coenzymes, Amino Acids, Peptides, and ProteinsSynonyms: (CYS74>SER,ALA245>THR)ADENOSINE DEAMINASE (BOS TAURUS, BOVINE)-(1-356)-PEPTIDE, PRODUCED IN ESCHERICHIA COLI, SUBSTITUTED ON N2 OF THE N-TERMINAL ALANYL RESIDUE (A1) AND ON N6 OF LYSYL RESIDUES (K) WITH, ON N.ALPHA..1ALANINE AND N6 OF LYSINE RESIDUES WITH
  3. Drug

    Dabocemagene autoficel

    go.drugbank.com/drugs/DB17878
    Investigational

    Dabocemagene autoficel is an _ex vivo_, autologous cell-based gene therapy. It comprises autologous dermal fibroblasts genetically modified to express functional type VII collagen. … Developed by Castle Creek Biosciences Inc., dabocemagene autoficel is being investigated for the treatment of dystrophic epidermolysis bullosa.[L46797]

    Synonyms: AUTOLOGOUS HUMAN DERMAL FIBROBLAST CELLS DERIVED FROM SKIN BIOPSIES, AND TRANSDUCED WITH A NON-REPLICATING, SELF-INACTIVATING LENTIVIRUS VECTOR THAT ENCODES HUMAN COLLAGEN TYPE VII ALPHA 1 (COL7A1) UNDER, 2004-TRANSDUCED HUMAN AUTOLOGOUS DYSTROPHIC EPIDERMOLYSIS BULLOSA DERMAL FIBROBLAST CELL FCX-007 INTEGRATED PROVIRAL HUMAN COLLAGEN TYPE VII TRANSGENE COL7A1 PLUS 5'-HUMAN CYTOMEGALOVIRUS PROMOTER/UTR-AND
  4. Drug

    TSHA-101

    go.drugbank.com/drugs/DB18280
    Investigational

    Synonyms: adeno-associated viral vector serotype 9 (AAV9) carrying both HEXA and HEXB
  5. Drug

    Yeast beta-D-glucan

    go.drugbank.com/drugs/DB19271
    Investigational

    Yeast beta-D-glucan is under investigation in clinical trial NCT00632008 (Soluble Beta-glucan (SBG) as Treatment for Diabetic Foot Ulcers).

    Synonyms: -glucan from saccharomyces cerevisiae, Microparticulate beta-(1,3)(1,6) glucan from saccharomyces cerevisiae
  6. Drug

    Atidarsagene autotemcel

    go.drugbank.com/drugs/DB17538
    ApprovedInvestigational

    [L45191] Libmeldy was granted orphan designation by the EMA in April 2007, and was issued a marketing authorization in the EU in December 2020 for the treatment of certain manifestations of metachromatic … Atidarsagene autotemcel, sold under the brand name Libmeldy, is a gene therapy comprising genetically modified autologous CD34+ enriched hematopoietic stem and progenitor cells transduced _ex vivo_ using

    Categories: Enzymes and Coenzymes, Alimentary Tract and MetabolismSynonyms: Autologous CD34+ cell enriched population that contains haematopoietic stem and progenitor cells (HSPC) transduced ex vivo using a lentiviral vector encoding the human arylsulfatase A (ARSA) gene
  7. Drug

    MM-111

    go.drugbank.com/drugs/DB17983
    Investigational

    MM-111 is a novel bispecific antibody fusion protein that co-targets the the epidermal growth factor family receptor tyrosine kinases, ERBB2 and ERBB3.

    Categories: Amino Acids, Peptides, and ProteinsSynonyms: Antibody bispecific for erbb2 and erbb3
  8. Drug

    Afamitresgene autoleucel

    go.drugbank.com/drugs/DB18592
    ApprovedInvestigational

    [L51114, L51119] Afamitresgene autoleucel is first prepared from the patient’s peripheral blood mononuclear cells (PBMCs), which are enriched for T cells and are then transduced with a replication-incompetent … [L51114] MAGE-A4 is an intracellular cancer-testis antigen that is overexpressed by cancer cells in synovial sarcoma.

    Synonyms: AUTOLOGOUS CD4+ AND CD8+ T CELLS OBTAINED BY LEUKAPHERESIS, TRANSDUCED WITH AN HIV-DERIVED SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR, ENCODING AN ENHANCED-AFFINITY T CELL RECEPTOR (TCR) SPECIFIC FOR THE
  9. Drug

    Cenplacel-L

    go.drugbank.com/drugs/DB19188
    Investigational

    Cenplacel-L is under investigation in clinical trial (Study of Human Placenta-derived Cells (PDA001) to Evaluate the Safety and Effectiveness for Patients With Ischemic Stroke) for the treatment of patients

    Synonyms: CELLULAR IDENTITY: MESENCHYMAL-LIKE STROMAL CELL: CD34-, CD10+, CD105+, AND CD200+., HUMAN PLACENTA-DERIVED ADHERENT (PDA) CELLS THAT ARE CULTURE-EXPANDED, UNDIFFERENTIATED MESENCHYMAL-LIKE CELLS DERIVED FROM FULL-TERM PLACENTAL TISSUE.
  10. Drug

    Romilkimab

    go.drugbank.com/drugs/DB16318
    Investigational

    Romilkimab is under investigation in clinical trial NCT02345070 (Efficacy and Safety of SAR156597 in the Treatment of Idiopathic Pulmonary Fibrosis).

    Synonyms: Bispecific antibody targeting interleukin 4 (IL-4) and interleukin 13 (IL-13)