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Osimertinib
go.drugbank.com/drugs/DB09330ApprovedInvestigationalIn contrast, third-generation inhibitors are specific for the gate-keeper T790M mutations which increases ATP binding activity to EGFR and result in poor prognosis for late-stage disease. … testing and which has progressed following therapy with a first-generation EGFR tyrosine kinase inhibitor.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexGolimumab
go.drugbank.com/drugs/DB06674ApprovedInvestigationalulcerative colitis (UC) who require chronic steroids or have experienced intolerance or only a partial response to previous medications. … Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate treatment in patients with moderate to severe active rheumatoid arthritis (RA), (ii) alone or as an adjunct to methotrexate
Categories: Biologics for Rheumatoid Arthritis TreatmentProducts: Concentrate for Solution for Infusion 12.5mg/1 ml, SIMPONI IV 12.5mg/1ml Concentrate for Solution for InfusionMaraviroc
go.drugbank.com/drugs/DB04835ApprovedInvestigationalMaraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the … It was approved for use by the FDA in August, 2007.
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UsePretomanid
go.drugbank.com/drugs/DB05154ApprovedInvestigationalPersistent forms of tuberculosis (TB) have proven to be a major cause of global morbidity and mortality and a cause for significant concern. … [L8048,L8066] Unlike other therapeutic regimens for the treatment of resistant TB, which may take 18 months or longer and may not be effective, the pretomanid-containing regimen allows for a more efficacious
Categories: Antiinfectives for Systemic Use, Drugs for Treatment of TuberculosisInositol
go.drugbank.com/drugs/DB13178ApprovedInvestigationalWithdrawnIt is considered a pseudovitamin as it is a molecule that does not qualify to be an essential vitamin because even though its presence is vital in the body, a deficiency in this molecule does not translate … Inositol is a collection of nine different stereoisomers but the name is usually used to describe only the most common type of inositol, myo-inositol.
Mixtures: Twin Opti Pwr, Formula Pro-BSynonyms: L-myo-InositolSulisobenzone
go.drugbank.com/drugs/DB11185ApprovedAs a group, benzophenones may be used to delay photodegradation or extend shelf life in toiletries and plastic surface coatings [L2671]. … The benzophenones are a group of aromatic ketones that have both pharmaceutical and industrial applications [L2671]. Benzophenones may be found organically in fruits such as grapes [L2669].
Mixtures: CD Hydra Life Pro-Youth Protective Fluid, CD Hydra Life Pro-Youth Protective SPF 15Bacillus calmette-guerin substrain connaught live antigen
go.drugbank.com/drugs/DB10804ApprovedInvestigationalWithdrawnor recurrent stage Ta and/or T1 papillary tumors following transurethral resection (TUR). … Bacillus calmette-guerin substrain connaught live antigen is intravesically administered for the treatment and prophylaxis of carcinoma in situ (CIS) of the urinary bladder and for the prophylaxis of primary
Insulin lispro
go.drugbank.com/drugs/DB00046ApprovedInvestigationalThese biochemical changes result in a reduced tendency for self-association resulting in dissolution to a dimer and then to a monomer that is absorbed more rapidly after subcutaneous injection compared … Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.
Mixtures: HUMALOG MIX 25 SUSPENSION FOR INJECTION 100 iu/ml, HUMALOG MIX 25 SUSPENSION FOR INJECTION 100 iu/mlCategories: Insulins and Analogues for Injection, Fast-ActingBebtelovimab
go.drugbank.com/drugs/DB16755ApprovedWithdrawnBebtelovimab (LY-COV1404, LY-3853113) is a human monoclonal antibody approved for emergency use in the treatment of COVID-19. … [L43827] On November 30, 2022, the EUA for bebtelovimab was officially withdrawn due to a lack of efficacy against Omicron subvariants, therefore bebtelovimab is no longer authorized for emergency use
Categories: Approved Treatments for COVID-19Hexylresorcinol
go.drugbank.com/drugs/DB11254ApprovedHexylresorcinol is a substituted dihydroxybenzene. It exhibits antiseptic, anthelmintic, and local anesthetic properties. … It can be found in topical applications for minor skin infections and in oral solutions or throat lozenges for pain relief and first aid antiseptic.