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Rugonersen
go.drugbank.com/drugs/DB18662InvestigationalRugonersen is a locked nucleic acid antisense oligonucleotide under investigation for the treatment of Angelman Syndrome.
Veverimer
go.drugbank.com/drugs/DB18977InvestigationalVeverimer is under investigation in clinical trial NCT03390842 (Long-term Safety Extension to Study TRCA-301).
Synonyms: 1,3-propanediamine, n1,n3-di-2-propen-1-yl-, polymer with 1,2-dichloroethane and 2-propen-1-amine, N1,n3-bis(prop-2-en-1-yl)propan-1,3-diamine copolymer with 1,2-dichloroethane and prop-2-en-1-amineREM-422
go.drugbank.com/drugs/DB19304InvestigationalREM-422 is an orally bioavailable, small molecule mRNA degrader of the proto-oncogene c-Myb.
Synonyms: c-Myb mRNA degrader REM-422Mito-4509
go.drugbank.com/drugs/DB05846ExperimentalIt is used to treat Parkinson's Disease, Alzheimer's Disease, Retinal Disorders and other neurologic Disorders. … Mito-4509 is a non-feminizing estrogen analog that could affect mitochondrial metabolic pathways.
Opaganib
go.drugbank.com/drugs/DB12764Investigational[L27436] This drug has potential anticancer, anti-inflammatory, and antiviral activities, with potential applications in oncology, inflammation, the gastrointestinal system, and COVID-19. … Opaganib, also known as ABC294640, is a selective [sphingosine kinase-2 (SK2)](https://go.drugbank.com/polypeptides/Q9NRA0) inhibitor that is orally administered.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 4-Pyridinylmethyl 3(4-Chlorophenyl)Adamantine Carboxamide, 4-Pyridinylmethyl-3-(4-Chlorophenyl) Adamantine CarboxamideCelivarone
go.drugbank.com/drugs/DB16012InvestigationalCelivarone is under investigation in clinical trial NCT00233441 (Placebo Controlled Double-blind Dose Ranging Study of the Efficacy and Safety of SSR149744C 50, 100, 200 or 300 Mg OD With Amiodarone as … Calibrator for the Maintenance of Sinus Rhythm in Patients With Recent Atrial Fibrillation/flutter).
Categories: Heterocyclic Compounds, 2-RingSynonyms: Isopropyl 2-butyl-3-(4-(3-(dibutylamino)propyl)benzoyl)-1-benzofuran-5-carboxylateFB-825
go.drugbank.com/drugs/DB17598InvestigationalFB-825 is an investigational humanized monoclonal antibody that targets the CεmX domain of the membrane-bound IgE (mIgE), causing a depletion of mIgE positive B-cells. … It is currently being investigated for immune disorders, such as atopic dermatitis and hyperimmunoglobulin E syndrome (HIES).[A258448,L45743]
Synonyms: Recombinant humanized immunoglobulin gamma 1 monoclonal antibody (mAb) directed against the CemX segment of human membrane-bound immunoglobulin E (mIgE)Human ciliary neurotrophic factor, recombinant (E. coli)
go.drugbank.com/drugs/DB17959ExperimentalThe trials were NCT03071965, an extension study of the NT-501 CNTF implant for macular telangiectasia, and NCT01949324, a Phase 2 multicenter randomized clinical trial of CNTF for macular telangiectasia … type 2.
Synonyms: Human ciliary neurotrophic factor, recombinant (E. coli)Daledalin
go.drugbank.com/drugs/DB09189ExperimentalDaledin (UK-3557-15) is a selective norepinephrine reuptake inhibitor. It has no effects on the reuptake of serotonin or dopamine, and no antihistamine or anticholinergic properties. … It was in trials for depression in the 1970s but never marketed.
Categories: Heterocyclic Compounds, 2-RingTanespimycin
go.drugbank.com/drugs/DB05134InvestigationalIt is developed for the treatment of several types of cancer, solid tumors or chronic myelogenous leukemia. … Tanespimycin, manufactured by Conforma Therapeutics is under development as a small molecule inhibitor of heat shock protein 90 (HSP90).