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Peforelin
go.drugbank.com/drugs/DB21255ExperimentalPeforelin is a small molecule drug. The usage of the INN stem '-relin' in the name indicates that Peforelin is a pituitary hormone-release stimulating peptide. … Peforelin has a monoisotopic molecular weight of 1258.56 Da.
rAAV9-CMV-hNAGLUop
go.drugbank.com/drugs/DB33959ExperimentalrAAV9-CMV-hNAGLUop is a biologic drug. rAAV9-CMV-hNAGLUop is under investigation in clinical trial NCT07818759 (Single Injection of rAAV9-CMV-hNAGLUop Gene for Patients With Mucopolysaccharidosis (MPS)
Asparaginase Erwinia chrysanthemi
go.drugbank.com/drugs/DB08886ApprovedInvestigationalAsparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. … [L1448] L-asparaginase was first identified in 1963,[A236344] and there are different formulations of L-asparaginase, including [Asparaginase Escherichia coli] and a pegylated form of this enzyme, [Pegaspargase
Synonyms: Erwinia L-asparaginase, L-asparaginase (Erwinia)Carfilzomib
go.drugbank.com/drugs/DB08889ApprovedInvestigationalCarfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. … FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combination therapy.[L39392]
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, P-glycoprotein inhibitorsProducts: KYPROLIS®, KARFIB®Teduglutide
go.drugbank.com/drugs/DB08900ApprovedInvestigationalTeduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. … The significance of this substitution is that teduglutide is longer acting than endogenous GLP-2 as it is more resistant to proteolysis from dipeptidyl peptidase-4. FDA approved on December 21, 2012.
Categories: Glucagon-like Peptide-2 (GLP-2) Agonists, GLP-2 AnalogSynonyms: Gly(2)-GLP-2, (Gly2)GLP-2Dimethyl fumarate
go.drugbank.com/drugs/DB08908ApprovedInvestigationalIt is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated … Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.
Synonyms: (E)-But-2-enedioic acid dimethyl esterProducts: DIFUMY-MS®240 MG CÁPSULAS DURA, YARDIX® 240MGFerric carboxymaltose
go.drugbank.com/drugs/DB08917ApprovedInvestigationalFerric carboxymaltose is an iron replacement product and, chemically, an iron-carbohydrate complex. It was FDA approved on July 25, 2013.
Categories: Compounds used in a research, industrial, or household settingProducts: FERINJECT®, Ferinject® 50 mg iron/mL solution for injection/infusionPerospirone
go.drugbank.com/drugs/DB08922InvestigationalIt is commonly present as the hydrated hydrochloride salt form. … It is also shown to be less associated with extrapyramidal symptoms as a side effect compared to [DB00502].
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSynonyms: SM-9018, cis-N-(4-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)butyl)-1,2-cyclohexanedicarboximideAmfecloral
go.drugbank.com/drugs/DB08924ExperimentalIt acts as a prodrug which splits to form amphetamine and chloral hydrate, similarly to clobenzorex and related compounds, except that the N-substituent, in this case, yields a compound that is active … Amfecloral is a stimulant drug of the phenethylamine and amphetamine chemical classes.
Adrafinil
go.drugbank.com/drugs/DB08925ApprovedWithdrawnAdrafinil is metabolized to [modafinil]. … Adrafinil is a mild central nervous system stimulating drug typically employed to relieve excessive sleepiness and inattention in geriatric patients.