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Drug
Squalene
go.drugbank.com/drugs/DB11460
ApprovedInvestigationalVet approvedWithdrawn
It is a natural 30-carbon isoprenoid compound and intermediate metabolite in the synthesis of cholesterol. It is not susceptible to lipid peroxidation and provides skin protection.
Mixtures: K-OMEGASQUA (Softgel)Synonyms: (E,E,E,E)-Squalene, (all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene
Pathway
De Novo Triacylglycerol Biosynthesis TG(18:2(9Z,12Z)/18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z))
smpdb.ca/view/SMP0016020
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate
Pathway
De Novo Triacylglycerol Biosynthesis TG(18:2(9Z,12Z)/18:2(9Z,12Z)/20:4(8Z,11Z,14Z,17Z))
smpdb.ca/view/SMP0024292
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate
Pathway
De Novo Triacylglycerol Biosynthesis TG(18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z)/18:2(9Z,12Z))
smpdb.ca/view/SMP0024305
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate
Pathway
De Novo Triacylglycerol Biosynthesis TG(18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z)/22:2(13Z,16Z))
smpdb.ca/view/SMP0024307
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate
Pathway
De Novo Triacylglycerol Biosynthesis TG(18:2(9Z,12Z)/22:2(13Z,16Z)/20:4(5Z,8Z,11Z,14Z))
smpdb.ca/view/SMP0024318
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate
Pathway
De Novo Triacylglycerol Biosynthesis TG(18:2(9Z,12Z)/22:2(13Z,16Z)/20:4(8Z,11Z,14Z,17Z))
smpdb.ca/view/SMP0024324
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate
Pathway
De Novo Triacylglycerol Biosynthesis TG(18:2(9Z,12Z)/18:4(6Z,9Z,12Z,15Z)/18:2(9Z,12Z))
smpdb.ca/view/SMP0024364
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate
Pathway
De Novo Triacylglycerol Biosynthesis TG(18:2(9Z,12Z)/18:4(6Z,9Z,12Z,15Z)/22:2(13Z,16Z))
smpdb.ca/view/SMP0024367
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate
Pathway
De Novo Triacylglycerol Biosynthesis TG(18:2(9Z,12Z)/20:4(8Z,11Z,14Z,17Z)/18:2(9Z,12Z))
smpdb.ca/view/SMP0024376
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate