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Displaying results 8551 - 8560 of 10000 in total

Drug
Trastuzumab deruxtecan
go.drugbank.com/drugs/DB14962
ApprovedInvestigational
Trastuzumab deruxtecan is a HER2-directed antibody attached to a topoisomerase inhibitor that is approved for use in certain types of treatment-resistant HER2-positive cancers.
Categories: MATE 2 Substrates, HER2 (Human Epidermal Growth Factor Receptor 2) inhibitorsSynonyms: T-DXd, T- DXd
Pathway
De Novo Triacylglycerol Biosynthesis TG(18:2(9Z,12Z)/18:2(9Z,12Z)/22:4(7Z,10Z,13Z,16Z))
smpdb.ca/view/SMP0016107
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate
Pathway
De Novo Triacylglycerol Biosynthesis TG(18:2(9Z,12Z)/22:2(13Z,16Z)/22:4(7Z,10Z,13Z,16Z))
smpdb.ca/view/SMP0024320
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate
Pathway
De Novo Triacylglycerol Biosynthesis TG(18:2(9Z,12Z)/22:4(7Z,10Z,13Z,16Z)/18:2(9Z,12Z))
smpdb.ca/view/SMP0024328
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate
Pathway
De Novo Triacylglycerol Biosynthesis TG(18:2(9Z,12Z)/22:4(7Z,10Z,13Z,16Z)/22:2(13Z,16Z))
smpdb.ca/view/SMP0024331
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate
Pathway
De Novo Triacylglycerol Biosynthesis TG(20:4(5Z,8Z,11Z,14Z)/22:2(13Z,16Z)/22:2(13Z,16Z))
smpdb.ca/view/SMP0024886
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate
Pathway
De Novo Triacylglycerol Biosynthesis TG(22:2(13Z,16Z)/18:2(9Z,12Z)/18:4(6Z,9Z,12Z,15Z))
smpdb.ca/view/SMP0025115
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate
Pathway
De Novo Triacylglycerol Biosynthesis TG(22:2(13Z,16Z)/22:2(13Z,16Z)/22:4(7Z,10Z,13Z,16Z))
smpdb.ca/view/SMP0025139
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate
Pathway
De Novo Triacylglycerol Biosynthesis TG(22:2(13Z,16Z)/22:2(13Z,16Z)/18:4(6Z,9Z,12Z,15Z))
smpdb.ca/view/SMP0025142
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate
Pathway
De Novo Triacylglycerol Biosynthesis TG(22:2(13Z,16Z)/22:2(13Z,16Z)/20:4(8Z,11Z,14Z,17Z))
smpdb.ca/view/SMP0025143
Metabolic
The enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase converts LPA into phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by esterifying an acyl-group to the sn-2 position of the glycerol backbone
Drugs: NADH · sn-glycerol 3-phosphate · Dihydroxyacetone phosphate