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Displaying results 8861 - 8870 of 10000 in total
  1. Drug

    Ecopipam

    go.drugbank.com/drugs/DB12273
    Investigational

    Ecopipam has been used in trials studying the treatment of Tourette's Syndrome, Lesch-Nyhan Disease, Pathological Gambling, and Self-injurious Behavior.

    Categories: Heterocyclic Compounds, 2-Ring
  2. Drug

    Seviteronel

    go.drugbank.com/drugs/DB12275
    Investigational

    Seviteronel has been used in trials studying the treatment of CRPC, Prostate Cancer, and Castration-resistant Prostate Cancer.

    Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 Enzyme Inhibitors
  3. Drug

    Luspatercept

    go.drugbank.com/drugs/DB12281
    ApprovedInvestigational

    Luspatercept is a recombinant fusion protein comprised of a modified extracellular domain of activin receptor type IIB fused to the FC domain of human IgG1. … [A187835] Luspatercept's novel mechanism of action, then, is uniquely suited for the treatment of conditions in which late-stage erythropoiesis is defective, such as beta thalassemia and other myelodysplastic

    Products: REBLOZYL®
  4. Drug

    Defactinib

    go.drugbank.com/drugs/DB12282
    ApprovedInvestigational

    Defactinib is a small molecule kinase inhibitor targeted against focal adhesion kinase (FAK) and proline-rich tyrosine kinase-2 (Pyk2), the two members of the FAK family of nonreceptor tyrosine kinases … [L53198,L53208] FAK is important for the integrin-mediated activation of several downstream signal transduction pathways, including those involving RAS/MEK/ERK and PI3K/Akt, and its upregulation is a key

    Synonyms: N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamideCategories: MATE 2 Inhibitors, Cytochrome P-450 Substrates
  5. Drug

    Balapiravir

    go.drugbank.com/drugs/DB12283
    Investigational

    Balapiravir has been used in trials studying the treatment of Dengue and Hepatitis C, Chronic.

  6. Drug

    LY-2608204

    go.drugbank.com/drugs/DB12284
    Investigational

    LY2608204 has been used in trials studying the treatment of Diabetes Mellitus, Type 2.

    Categories: Heterocyclic Compounds, 1-Ring
  7. Drug

    Verubecestat

    go.drugbank.com/drugs/DB12285
    Investigational

    Verubecestat is Merck’s investigational oral β-site amyloid precursor protein cleaving enzyme (BACE1 or β secretase) inhibitor. … In the study, administration of Verubecestat at doses of 12, 40 and 60 mg resulted in a dose-dependent and sustained reduction in the levels of Ab40, a measure of BACE1 activity, in CSF from baseline of

    Categories: Heterocyclic Compounds, 1-Ring
  8. Drug

    Simendan

    go.drugbank.com/drugs/DB12286
    Experimental

    Categories: Heterocyclic Compounds, 1-Ring, Phosphodiesterase 3 Inhibitors
  9. Drug

    Piromelatine

    go.drugbank.com/drugs/DB12288
    Investigational

    Piromelatine has been used in trials studying the treatment of Alzheimer's Disease.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  10. Drug

    Puerarin

    go.drugbank.com/drugs/DB12290
    Investigational

    Puerarin has been investigated for the treatment of Alcohol Abuse.

    Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring