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Binodenoson
go.drugbank.com/drugs/DB04853InvestigationalThis specificity allows Binodenoson to deliver - in a single injection - a more effective dose of medication with fewer side effects than current treatments, which typically require a 15-20 minute infusion … Binodenoson is a pharmacologic stress agent specific to the only adenosine receptor necessary for increased cardiac blood flow, the A<sub>2A</sub> receptor.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 2-((Cyclohexylmethylene)hydrazino)adenosineBrasofensine
go.drugbank.com/drugs/DB04857ExperimentalPhase I/II trials for brasofensine have been completed in the U.K. In November 2001, NeuroSearch confirmed that the drug's development was discontinued in favor of NS 2230.
Tirapazamine
go.drugbank.com/drugs/DB04858InvestigationalThis activation is very useful as this hypoxic state is found in human solid tumors in a common phenomenon known as tumor hypoxia.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingSynonyms: 1,2,4-benzotriazin-3-amine, 1,4-dioxide, 3-Amino-1,2,4-benzotriazine 1,4-dioxideOmacetaxine mepesuccinate
go.drugbank.com/drugs/DB04865ApprovedInvestigationalWithdrawnOmacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies
Categories: Heterocyclic Compounds, 2-Ring, Heterocyclic Compounds with 4 or More RingsSynonyms: 1-[(1S,3aR,14bS)-2-Methoxy-1,5,6,8,9,14b-hexahydro-4H-cyclopenta[a][1,3]dioxolo[4,5-H]pyrrolo[2,1-b][3]benzazepin-1-yl] 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate, CEPHALOTAXINE 4-METHYL (2R)-2-HYDROXY-2-(4-HYDROXY-4-METHYLPENTYL)BUTANEDIOATE (ESTER)Osanetant
go.drugbank.com/drugs/DB04872InvestigationalIn a review of its R&D portfolio, the company announced in August 2005 that it would cease any further development of osanetant.
Categories: Heterocyclic Compounds, 1-RingVildagliptin
go.drugbank.com/drugs/DB04876ApprovedInvestigationalVildagliptin (LAF237) is an orally active antihyperglycemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme. … [A232488] By inhibiting DPP-4, vildagliptin prevents the degradation of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which are incretin hormones that promote
Mixtures: JALRA ®M 50 MG /500 MG, JALRA® M 50 MG / 850 MGCategories: Glucagon-Like Peptide 1, P-glycoprotein substratesVoglibose
go.drugbank.com/drugs/DB04878InvestigationalVoglibose is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus. It is made in India by Ranbaxy Labs and sold under the trade name Volix.
Vatalanib
go.drugbank.com/drugs/DB04879InvestigationalVatalanib (PTK787/ZK-222584) is a new oral antiangiogenic molecule that inhibits all known vascular endothelial growth factor receptors.
Categories: Heterocyclic Compounds, 1-RingLanreotide
go.drugbank.com/drugs/DB06791ApprovedInvestigationalThis drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. … Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsProducts: SOMATULINE ® AUTOGEL ® 60 MG, Somatuline Autogel Prolonged Release Solution for Injection in a Pre-filled Syringe 120 mgMebutamate
go.drugbank.com/drugs/DB06797ApprovedMebutamate is a sedative and anxiolytic drug with anti-hypertensive (blood pressure lowering) effects comparable to those of other barbiturates but is only around 1/3rd the potency of secobarbital as a
Synonyms: 2-Methyl-2-sec-butyl-1,3-propanediol dicarbamate, 2-sec-Butyl-2-methyl-1,3-propanediol dicarbamate