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OTX-2002
go.drugbank.com/drugs/DB17246InvestigationalOTX-2002 is a bicistronic messenger ribonucleic acid (mRNA) encoding for ZF-DNMT and ZF-KRAB proteins, encapsulated in a lipid nanoparticle (LNP).
BNT111
go.drugbank.com/drugs/DB18177InvestigationalBNT111 is an investigational cancer immunotherapy under development for advanced melanoma. It consists of a fixed combination of mRNA-encoded, tumor-associated antigens.
Udifitimod
go.drugbank.com/drugs/DB19053InvestigationalUdifitimod is under investigation in clinical trial NCT05014438 (A Study of BMS-986166 or Branebrutinib for the Treatment of Participants With Atopic Dermatitis).
TNP-2092
go.drugbank.com/drugs/DB16312InvestigationalTNP-2092 is under investigation in clinical trial NCT03964493 (TNP-2092 to Treat Acute Bacterial Skin and Skin Structure Infection).
Tetraarsenic tetrasulfide
go.drugbank.com/drugs/DB19141InvestigationalTetraarsenic tetrasulfide is under investigation in clinical trial NCT05682131 (South China Children Cancer Group - Relapsed-acute Lymphoblastic Leukemia 2022 Protocol).
Substance P
go.drugbank.com/drugs/DB19198InvestigationalSubstance P is under investigation in clinical trial NCT03738878 (Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 1).
CIGB-258 peptide
go.drugbank.com/drugs/DB15809ExperimentalAs of 2020, The Center for Genetic Engineering and Biotechnology (CIGB) in Havana, Cuba, is testing the treatment efficacy of this peptide in patients with COVID-19 who are under intensive therapy regimens … CIGB-258 is a peptide that is immunoregulatory and derived from heat shock protein 60 of the cellular variant.
Gam-COVID-Vac
go.drugbank.com/drugs/DB15848InvestigationalJune 2020, and were completed in early August 2020. … The vaccine is offered in both a frozen (Gam-COVID-Vac) and freeze-dried formulation (lyophilizate; Gam-COVID-Vac Lyo).
ARCoV
go.drugbank.com/drugs/DB15855ExperimentalIt is the first COVID-19 mRNA vaccine to be approved for clinical trials in China, and was co-developed by Abogen Biosciences, Walvax Biotechnolgoy Co., Ltd. and the People’s Liberation Army (PLA) Academy … Preclinical studies in mice and non-human primates has shown that intramuscular administration of ARCoV elicited a Th1-biased cellular response and robust antibodies against SARS-CoV-2[A220048].
Tigapotide
go.drugbank.com/drugs/DB04985InvestigationalTigapotide is a synthetic 15-mer peptide that is derived from the natural sequence of amino acids of the prostate secretory protein (PSP94), one of three predominant proteins found in human seminal fluid