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Displaying results 961 - 970 of 10000 in total
  1. Drug

    Nortriptyline

    go.drugbank.com/drugs/DB00540
    ApprovedInvestigational

    [L11878] It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.[L11881]

    Synonyms: 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine, 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Δ5,γ-propylamineCategories: Adrenergic alpha-1 Receptor Antagonists
  2. Target

    20-ketosteroid reductase (20-hydroxysteroid dehydrogenase)

    go.drugbank.com/bio_entities/BE0009795
    EnzymeHumans and other mammals

    Catalyzes the inactivation of 5alpha-DHT and progesterone converting them into 3alpha/beta-androstanediols and (20S)-hydroxypregn-4-en-3-one, respectively (PubMed:10998348, PubMed:24434280). … Catalyzes the reduction of progesterone to less potent progestogen (20S)-hydroxypregn-4-en-3-one likely regulating ligand availability for progesterone receptors (PubMed:10998348, PubMed:11013348, PubMed

    Synonyms: 20-alpha-HSDFunction: 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity
  3. Drug

    Pegfilgrastim

    go.drugbank.com/drugs/DB00019
    ApprovedInvestigational

    [L9746] Although the risk of developing febrile neutropenia is less than 20% in many readily used chemotherapy regimens,[A248855] infections pose risks of hospitalization and mortalities. … [A187631] Due to the relatively short circulating half-life of filgrastim, a 20 kDa PEG moiety was covalently conjugated to the N-terminus of filgrastim (at the methionine residue) to develop longer-acting

    Synonyms: PEG-G-CSF, Pegylated G-CSFCategories: Compounds used in a research, industrial, or household setting
  4. Drug

    Estramustine

    go.drugbank.com/drugs/DB01196
    ApprovedWithdrawn

    A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.

    Synonyms: Estradiol 3-(N,N-bis(2-chloroethyl)carbamate), 17β-Estradiol 3-(bis(2-chloroethyl)carbamate)Products: ESTRACYT 300 MG ENJEKTABL FLAKON, 10 ADET, ESTRACYT 140 MG KAPSUL, 100 ADET
  5. Drug

    Sirolimus

    go.drugbank.com/drugs/DB00877
    ApprovedInvestigational

    [A1320] Sirolimus was first approved by the FDA in 1999 for the prophylaxis of organ rejection in patients aged 13 years and older receiving renal transplants. … [A242417] Targeting mTOR received more attention especially in cancer, as mTOR signalling pathways are constitutively activated in many types of human cancer.

    Products: RAPAMUNE 1 MG FILM DRAJE, 30 ADET, RAPAMUNE 1 MG/ML 60 ML ORAL SOLUSYON
  6. Drug

    Abiraterone

    go.drugbank.com/drugs/DB05812
    ApprovedInvestigational

    Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis … [A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April,[A260880] July,[L47745] and September 2011,[A260880] respectively.

    Synonyms: 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol, (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-olProducts: ABYGA 250 MG TABLET, 120 ADET, ZYTIGA 250 MG TABLET, 120 ADET
  7. Drug

    Flucytosine

    go.drugbank.com/drugs/DB01099
    ApprovedInvestigational

    A fluorinated cytosine analog that is used as an antifungal agent.

    Categories: Heterocyclic Compounds, 1-RingProducts: FLUSYNERG® 10 MG/ML SOLUCIÓN INYECTABLE, Ancotil 2,5 g/250 ml -Infusionsflaschen
  8. Drug

    Pimozide

    go.drugbank.com/drugs/DB01100
    Approved

    A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome.

    Categories: Heterocyclic Compounds, 2-RingProducts: NOROFREN 2 MG TABLET, 10 ADET, NOROFREN 2 MG TABLET, 20 ADET
  9. Drug

    Secnidazole

    go.drugbank.com/drugs/DB12834
    ApprovedInvestigational

    [A245503] Secnidazole has been available in many other countries in Europe, Asia, South America, and Africa for decades. … [A245503, A245508] In September 2017, FDA approved secnidazole under the market name Solosec for the treatment of trichomoniasis and bacterial vaginosis.[L39524]

    Synonyms: 1-(2-methyl-5-nitro-1H-imidazol-1-yl) propan-2­ ol, 1-(2­ hydroxypropyl)-2-methyl-5-nitroimidazoleMixtures: ITRACONAZOL 33.3 MG + SECNIDAZOL 166.66 MG CÁPSULA, FLUCONAZOL+SECNIDAZOL 75MG/1000 MG
  10. Drug

    Trastuzumab

    go.drugbank.com/drugs/DB00072
    ApprovedInvestigational

    It is suggested that the overexpression or gene amplification of HER2 has been found in about 20–30% of breast cancers and elevated activation of HER2 triggers multiple downstream pathways leading to abnormal … -2 protein in tumours.

    Mixtures: PHESGO® 1200 MG/600 MG, PHESGO® 1200 MG/600 MGCategories: HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors