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JTC-801 free base
go.drugbank.com/drugs/DB17033ExperimentalAn antagonist of nociceptin receptor and analgesic agent, evaluated for its use in cancer treatment.[A253027]
Categories: Heterocyclic Compounds, 2-RingSynonyms: Benzamide, n-(4-amino-2-methyl-6-quinolinyl)-2-((4-ethylphenoxy)methyl)-Alcuronium
go.drugbank.com/drugs/DB13648ExperimentalA non-depolarizing skeletal muscle relaxant similar to [tubocurarine]. It is used as an anesthesia adjuvant.
Categories: Heterocyclic Compounds, 2-RingSynonyms: N,N'-Diallylnortoxiferinium, N,N'-diallyl-bis-nor-toxiferineAnti-SARS-CoV-2 REGN-COV2
go.drugbank.com/drugs/DB15691InvestigationalThis drug is a combination of the antibodies REGN10933 and REGN10987, derived from humanized VelocImmune® mice in addition to blood samples from patients who have recovered from COVID-19. … [L14303] Two upcoming publications in the journal, _Science_, will provide additional information about preclinical research with the Anti-SARS-COV-2 REGN-COV2 antibody cocktail.
Synonyms: Anti-SARS-CoV-2 REGN-COV2Simurosertib
go.drugbank.com/drugs/DB16330InvestigationalSimurosertib is under investigation in clinical trial NCT03261947 (A Study to Evaluate the Safety, Tolerability, and Activity of TAK-931 in Participants With Metastatic Pancreatic Cancer, Metastatic Colorectal
Categories: Heterocyclic Compounds, 1-RingSynonyms: 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-oneBMS-986104
go.drugbank.com/drugs/DB15214InvestigationalBMS-986104 is under investigation in clinical trial NCT02211469 (A Randomized, Placebo-Controlled, Double-Blind, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics … of BMS-986104 in Healthy Male Subjects).
Vabametkib
go.drugbank.com/drugs/DB21629InvestigationalVabametkib is under investigation in clinical trial NCT05541822 (To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetic Profile of ABN401 in Patients With Advanced Solid Tumors Harboring c-MET … Vabametkib is a small molecule drug.
Olinvacimab
go.drugbank.com/drugs/DB16265InvestigationalOlinvacimab is under investigation in clinical trial NCT03033524 (Trial to Evaluate the Safety of Ttac-0001(tanibirumab) in Recurrent Glioblastoma).
Synonyms: Fully human monoclonal antibody targets vascular endothelial growth factor receptor 2, Immunoglobulin g1, anti-(human vascular endothelial growth factor receptor 2) (human monoclonal ttac-0001 heavy chain), disulfide with human monoclonal ttac-0001 light chain, dimerOlodanrigan
go.drugbank.com/drugs/DB16266InvestigationalOlodanrigan is under investigation in clinical trial NCT03297294 (Safety and Efficacy of EMA401 in Patients With Painful Diabetic Neuropathy (PDN)).
Categories: Heterocyclic Compounds, 2-RingRomilkimab
go.drugbank.com/drugs/DB16318InvestigationalRomilkimab is under investigation in clinical trial NCT02345070 (Efficacy and Safety of SAR156597 in the Treatment of Idiopathic Pulmonary Fibrosis).
Synonyms: Bispecific antibody targeting interleukin 4 (IL-4) and interleukin 13 (IL-13)Torudokimab
go.drugbank.com/drugs/DB16671InvestigationalTorudokimab is under investigation in clinical trial NCT03831191 (A Study of LY3375880 in Adults With Moderate-to-severe Atopic Dermatitis).