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Futibatinib
go.drugbank.com/drugs/DB15149ApprovedInvestigationalFutibatinib is an inhibitor of Fibroblast Growth Factor receptor (FGFR), which comprises a group of receptor tyrosine kinases that play a key role in cell proliferation, differentiation, migration, and … FGFR was investigated in oncology as a therapeutic target, as FGFR genomic aberrations and dysregulated FGFR signalling pathways are observed in some cancers such as cholangiocarcinoma and urothelial malignancies
Synonyms: 1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one, 1-((3S)-(4-amino-3-((3,5-dimethoxyphenyl)ethynyl)-1H-pyrazolo(3, 4-d) pyrimidin-1-yl)-1-pyrrolidinyl)-2-propen-1-oneCategories: P-glycoprotein inhibitors, P-glycoprotein substratesLisocabtagene maraleucel
go.drugbank.com/drugs/DB16582ApprovedInvestigational[A228493] Despite the adverse reactions, the majority of patients given lisocabtagene maraleucel reported an overall increase in quality of life over a 1 year period. … [L43322] In 2025, the FDA also approved lisocabtagene maraleucel as the first CAR T-cell therapy in the United States for adult patients with relapsed or refractory marginal zone lymphoma (MZL).
Categories: CD19-Directed Genetically Modified Autologous T-cell ImmunotherapiesDe Novo Triacylglycerol Biosynthesis TG(a-21:0/a-13:0/i-13:0)
smpdb.ca/view/SMP0038260MetabolicThey are also present in the blood to enable the bidirectional transference of adipose fat and blood glucose from the liver, and are a major component of human skin oils. … All membrane-localized enzymes are coloured dark green in the image.
De Novo Triacylglycerol Biosynthesis TG(a-21:0/a-13:0/i-14:0)
smpdb.ca/view/SMP0038261MetabolicThey are also present in the blood to enable the bidirectional transference of adipose fat and blood glucose from the liver, and are a major component of human skin oils. … All membrane-localized enzymes are coloured dark green in the image.
De Novo Triacylglycerol Biosynthesis TG(a-21:0/a-13:0/i-15:0)
smpdb.ca/view/SMP0038262MetabolicThey are also present in the blood to enable the bidirectional transference of adipose fat and blood glucose from the liver, and are a major component of human skin oils. … All membrane-localized enzymes are coloured dark green in the image.
De Novo Triacylglycerol Biosynthesis TG(a-21:0/a-13:0/i-19:0)
smpdb.ca/view/SMP0038265MetabolicThey are also present in the blood to enable the bidirectional transference of adipose fat and blood glucose from the liver, and are a major component of human skin oils. … All membrane-localized enzymes are coloured dark green in the image.
De Novo Triacylglycerol Biosynthesis TG(a-21:0/a-13:0/i-21:0)
smpdb.ca/view/SMP0038267MetabolicThey are also present in the blood to enable the bidirectional transference of adipose fat and blood glucose from the liver, and are a major component of human skin oils. … All membrane-localized enzymes are coloured dark green in the image.
De Novo Triacylglycerol Biosynthesis TG(a-21:0/a-13:0/i-22:0)
smpdb.ca/view/SMP0038268MetabolicThey are also present in the blood to enable the bidirectional transference of adipose fat and blood glucose from the liver, and are a major component of human skin oils. … All membrane-localized enzymes are coloured dark green in the image.
De Novo Triacylglycerol Biosynthesis TG(a-21:0/a-15:0/i-12:0)
smpdb.ca/view/SMP0038287MetabolicThey are also present in the blood to enable the bidirectional transference of adipose fat and blood glucose from the liver, and are a major component of human skin oils. … All membrane-localized enzymes are coloured dark green in the image.
De Novo Triacylglycerol Biosynthesis TG(a-21:0/a-15:0/i-14:0)
smpdb.ca/view/SMP0038289MetabolicThey are also present in the blood to enable the bidirectional transference of adipose fat and blood glucose from the liver, and are a major component of human skin oils. … All membrane-localized enzymes are coloured dark green in the image.