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gamma-Aminobutyric acid
The most common inhibitory neurotransmitter in the central nervous system.
Vigabatrin
go.drugbank.com/drugs/DB01080ApprovedInvestigationalVigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms.
Categories: Acids, Acyclic, Fatty AcidsSynonyms: gamma-Vinyl-gamma-aminobutyric acid, Vinyl gamma-aminobutyric acidBaclofen
go.drugbank.com/drugs/DB00181ApprovedInvestigationalBaclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant.
Categories: gamma-Aminobutyric Acid-ergic Agonist, Amino AcidsSynonyms: beta-(p-Chlorophenyl)-gamma-aminobutyric acid, gamma-Amino-beta-(p-chlorophenyl)butyric acidLindane
go.drugbank.com/drugs/DB00431ApprovedWithdrawnAn organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on t...
Synonyms: gamma-BHC, gamma-HCHProducts: Gamma Benzene Hexachloride Lotion USP 1% w/v (LICSCAB Lotion)Clorazepic acid
go.drugbank.com/drugs/DB00628ApprovedIllicitSimilar to other benzodiazepines, the active metabolite of clorazepate enhances the binding of gamma-aminobutyric acid (GABA) to the GABA type A (GABA-A) receptor, which promotes channel opening and neuronal … Clorazepic acid (clorazepate) is a water-soluble benzodiazepine with muscle-relaxant and anticonvulsant actions effective in the treatment of anxiety.
Synonyms: Clorazepic acid, 7-chloro-2,3-dihydro-2,2-dihydroxy-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acidAminooxyacetic acid
go.drugbank.com/drugs/DB02079ExperimentalA compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues. [PubChem]
Synonyms: aminoxyacetic acid, (aminooxy)acetic acidCategories: Acids, Acyclic, Carboxylic AcidsPhenobarbital
go.drugbank.com/drugs/DB01174ApprovedInvestigationalIt promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. … A barbituric acid derivative that acts as a nonselective central nervous system depressant.
Categories: Excitatory Amino Acid Agents, Excitatory Amino Acid AntagonistsSynonyms: Phenobarbituric Acid, Phenylethylbarbituric AcidGabapentin
go.drugbank.com/drugs/DB00996ApprovedInvestigationalGabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993.
Categories: Amino Acids, Acids, AcyclicSynonyms: 1-(Aminomethyl)cyclohexaneacetic acidbeta-Alanine
go.drugbank.com/drugs/DB03107InvestigationalSince neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBUTYRIC ACID. … beta-Alanine is an amino acid formed in vivo by the degradation of [dihydrouracil] and [carnosine].
Synonyms: 3-aminopropanoic acid, 3-aminopropionic acidCategories: Amino Acids, Amino Acids, Peptides, and ProteinsBrexanolone
go.drugbank.com/drugs/DB11859ApprovedInvestigationalAs of March 2019, brexanolone - developed and made available commercially by Sage Therapeutics Inc. as the brand name product Zulresso - is the first drug to have ever been approved by the US FDA specifically for the treatment of postpar...
Categories: Neuroactive Steroid Gamma-Aminobutyric Acid A Receptor Positive Modulator, Neuroactive Steroid Gamma-Aminobutyric Acid (GABA) A Receptor Positive Modulators