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  1. Pathway

    Cyclophosphamide Metabolism Pathway

    smpdb.ca/view/SMP0000604
    Drug metabolism

    Cyclophosphamide is an alkylating agent used in the treatment of certain cancers. … Following absorption, cyclophosphamide is converted into 4-hydroxyphosphamide by a variety of cytochrome P450 isozymes in the liver. 4-Hydroxyphosphamide is more soluble than cyclophosphamide and is the

    Drugs: Glutathione · NADH · Cyclophosphamide · Mesoheme · Acrylic Acid
  2. Pathway

    Cyclophosphamide Action Pathway

    smpdb.ca/view/SMP0000447
    Drug action

    Cyclophosphamide is an alkylating agent used in the treatment of certain cancers. … Following absorption, cyclophosphamide is converted into 4-hydroxyphosphamide by a variety of cytochrome P450 isozymes in the liver. 4-Hydroxyphosphamide is more soluble than cyclophosphamide and is the

    Drugs: Glutathione · NADH · Cyclophosphamide · Mesoheme · Acrylic Acid
  3. Pathway

    Cyclophosphamide Action Pathway (New)

    smpdb.ca/view/SMP0122835
    Drug action

    Cyclophosphamide is an antineoplastic alkylating agent used to treat lymphoma and leukemia. … Because the metabolism of cyclophosphamide is linked with the production of the active cytotoxic agent, cyclophosphamide induces its own metabolism with results in an increase in blood plasma clearance

    Drugs: NADH · Adenine · Cyclophosphamide · Mesoheme · Acrylic Acid