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  1. Pathway

    Nilotinib Predicted Metabolism Pathway

    smpdb.ca/view/SMP0174600
    Metabolic

    Metabolites of Nilotinib are predicted with biotransformer.

    Drugs: Mesoheme · Nilotinib
  2. Pathway

    Nilotinib Inhibition of BCR-ABL Action Pathway

    smpdb.ca/view/SMP0031697
    Drug action

    Notably, Nilotinib is ineffective against the T315I mutation in BCR-ABL, and further research is necessary. … Nilotinib is able to bind ABL with greater affinity than Imatinib (20-fold to 30-fold increase). It is therefore administered to patients with Imatinib resistance.

    Drugs: Nilotinib