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Pazopanib
go.drugbank.com/drugs/DB06589
ApprovedInvestigational
Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Fruquintinib
go.drugbank.com/drugs/DB11679ApprovedInvestigational[A262097] For the small-molecule approach, most earlier generations of VEGFR inhibitors such as [sunitinib], [sorafenib], [regorafenib], and [pazopanib] have poor selectivity, thus increasing the risk