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Prademagene zamikeracel
go.drugbank.com/drugs/DB17895ApprovedInvestigational[A273833,A273838] Patient cells are then transduced ex vivo with a replication-incompetent retroviral vector (RVV) containing the full-length COL7A1 gene, resulting in cells that express functional collagen … [L53013] It was granted an Orphan Drug designation by the EMA.[A273833]
Synonyms: Ex-vivo-expanded autologous keratinocytes transduced with retroviral vector containing the COL7A1 gene, Ex-vivo-expanded autologous keratinocytes transduced with retroviral vector containing the human COL7A1 geneEx vivo expanded autologous human corneal epithelial cells containing stem cells
go.drugbank.com/drugs/DB18660ApprovedWithdrawnHoloclar (_ex vivo_ expanded autologous human corneal epithelial cells containing stem cells) is a stem cell therapy used to treat limbal stem cell deficiencies.[L48375]
Synonyms: Ex vivo expanded autologous human corneal epithelial cells containing stem cellsOmidubicel
go.drugbank.com/drugs/DB17132ApprovedInvestigationalUmbilical blood cord cells are expanded _ex-vivo_ and [nicotinamide] (a form of vitamin B3) is used as an active agent in the culture system to inhibit the differentiation and increase the functionality … In this group of patients, umbilical cord blood can be used as an alternative cell source since there is a lower risk of graft failure or graft-versus-host disease, even with low-grade HLA-matching.
Synonyms: Allogeneic, ex-vivo expanded, umbilical cord blood-derived hematopoietic CD34+ progenitor cells - cultured fraction (CF)Marnetegragene autotemcel
go.drugbank.com/drugs/DB17595Approved[L56115, L56116] Marnetegragene autotemcel is indicated for pediatric patients with severe LAD-I lacking an available HLA-matched sibling donor.[L56115] … [L56116, A275467] Marnetegragene autotemcel, also known as marne-cel, is an autologous hematopoietic stem cell-based gene therapy created from the patient's own hematopoietic stem cells.
Synonyms: Autologous CD34+ cells transduced ex vivo with a lentiviral vector (Chim-CD18-WPRE) encoding the ITGB2 geneCarlecortemcel-L
go.drugbank.com/drugs/DB17186InvestigationalSynonyms: Allogeneic ex vivo expanded umbilical cord blood cellsAvoplacel
go.drugbank.com/drugs/DB18659InvestigationalAvoplacel (PLX-R18) is an allogeneic cell therapy under investigation for the treatment of acute radiation syndrome.[L48370]
Synonyms: Ex-vivo expanded placental adherent stromal cellsDCVAC/OvCa
go.drugbank.com/drugs/DB18571InvestigationalDCVAC/OvCa is a therapy comprising autologous dendritic cells pulsed with killed ovarian cancer cells and matured by TLR3 ligand _ex vivo_.
Synonyms: Autologous dendritic cells pulsed with killed ovarian cancer cells and matured by TLR3 ligand ex vivoAtidarsagene autotemcel
go.drugbank.com/drugs/DB17538ApprovedInvestigational[L45191] Libmeldy was granted orphan designation by the EMA in April 2007, and was issued a marketing authorization in the EU in December 2020 for the treatment of certain manifestations of metachromatic … Atidarsagene autotemcel, sold under the brand name Libmeldy, is a gene therapy comprising genetically modified autologous CD34+ enriched hematopoietic stem and progenitor cells transduced _ex vivo_ using
Synonyms: Autologous CD34+ cell enriched population that contains haematopoietic stem and progenitor cells (HSPC) transduced ex vivo using a lentiviral vector encoding the human arylsulfatase A (ARSA) geneTaraxacum officinale leaf
go.drugbank.com/drugs/DB14342InvestigationalIt is not an approved drug.
Synonyms: Dandelion Leaf (Taraxacum Officinale Weber Ex Wigg.), Taraxaci Folium (Taraxacum Officinale Weber Ex Wigg.)Indian frankincense
go.drugbank.com/drugs/DB14275ApprovedInvestigationalIt is not an approved drug.
Synonyms: Ex Colebr. Oleo-gum-resin