Peptidoglycan D,D-transpeptidase FtsI

BE0000001ProteinHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)ftsI

Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. It is acted on by 2 drugs in DrugBank.

Gene name
ftsI
UniProtKB entry
P45059Swiss-Prot
Cellular location
Cell inner membrane
Residues / weight
610 residues · 67,166 Da
Also known as
2.4.1.129 · 3.4.16.4 · PBP-3 · Penicillin-binding protein 3 · Peptidoglycan glycosyltransferase 3

Resolves to

Protein
UniProtP45059UniProt nameFTSI_HAEIN
Gene
NCBI Gene950626GenBank1574687
Pharmacology
KEGGhin:HI1132
Drugs

What you can answer from here — as of May 03, 2025

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peptidoglycan D,D-transpeptidase FtsI, how selective are they, and which programs against it are still in active trials?

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