Ertapenem is a carbapenem antibiotic used for the treatment of moderate to severe infections caused by susceptible bacteria. Ertapenem is a 1-β methyl-carbapenem that is structurally related to beta-lactam antibiotics.
- Mechanism
- Curator reviewed · 4 references
Ertapenem exhibits a bactericidal mode of action. It works by binding to and inhibiting bacterial penicillin-binding proteins (PBPs). In Escherichia coli, it has a strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preferential binding to PBPs 2 and 3. Upon binding to PBPs, ertapenem inhibits bacterial cell wall synthesis by interfering with the lengthening and strengthening of the peptidoglycan portion of the cell wall, thereby inhibiting cell wall synthesis.
- Primary indication
- Ertapenem is indicated to treat the following moderate to severe infections caused by susceptible bacteria in adult and pediatric patients (three months of age and older): - Complicated intra-abdominal infections. - Complicated skin and skin...Curator reviewed · 20 structured indications
- Formula / weight
- C22H25N3O7S · 475.515 g/mol (avg)
- First approval
- Canada, 2005 · United States, 2001 · European Union, 2016
- Brand names
Resolves to
JUZNIMUFDBIJCM-ANEDZVCMSA-NSMILES[H][C@]12[C@@H](C)C(S[C@]3([H])CN[C@@]([H])(C3)C(=O)NC3=CC=CC(=C3)C(O)=O)=C(N1C(=O)[C@]2([H])[C@@H](C)O)C(O)=OWhat you can answer from here — as of September 12, 2026
Which drugs share a target with Ertapenem, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account