Glutaminase liver isoform, mitochondrial

BE0000003ProteinHumansGLS2

Plays an important role in the regulation of glutamine catabolism. It is acted on by 6 drugs in DrugBank.

Gene name
GLS2
UniProtKB entry
Q9UI32Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
602 residues · 66,322 Da
Also known as
3.5.1.2 · GA · GLS · L-glutaminase · L-glutamine amidohydrolase

Resolves to

Protein
UniProtQ9UI32UniProt nameGLSL_HUMAN
Gene
HGNCHGNC:29570NCBI Gene27165GenBank6650606GeneCardsGLS2
Pharmacology
KEGGhsa:27165
Structure
PDB4BQMPDB5U0KPDB8SZL
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutaminase liver isoform, mitochondrial, how selective are they, and which programs against it are still in active trials?

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