NAD(P) transhydrogenase, mitochondrial

BE0000008ProteinHumansNNT

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). It is acted on by 5 drugs in DrugBank.

Gene name
NNT
UniProtKB entry
Q13423Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
1,086 residues · 113,895 Da
Also known as
7.1.1.1 · Nicotinamide nucleotide transhydrogenase · Pyridine nucleotide transhydrogenase

Resolves to

Protein
UniProtQ13423UniProt nameNNTM_HUMAN
Gene
HGNCHGNC:7863NCBI Gene23530GenBank1110520GeneCardsNNT
Pharmacology
KEGGhsa:23530
Structure
PDB1DJLPDB1PT9PDB1U31
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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8GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NAD(P) transhydrogenase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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