G protein-coupled receptor kinase 3

BE0000018ProteinHumansGRK3

Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:21799898, PubMed:33859231). It is acted on by 1 drug in DrugBank.

Gene name
GRK3
UniProtKB entry
P35626Swiss-Prot
Cellular location
Postsynapse
Residues / weight
688 residues · 79,709 Da
Also known as
2.7.11.16 · ADRBK2 · BARK2 · Beta-adrenergic receptor kinase 2 · Beta-ARK-2

Resolves to

Protein
UniProtP35626UniProt nameGRK3_HUMAN
Gene
HGNCHGNC:290NCBI Gene157GenBank312395GeneCardsGRK3
Pharmacology
IUPHAR/GtoPdb1467KEGGhsa:157
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on G protein-coupled receptor kinase 3, and which indications are they being tested in?

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