Cystinosin

BE0000035ProteinHumansCTNS

Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes (PubMed:11689434, PubMed:15128704, PubMed:18337546, PubMed:22232659, PubMed:29467429, PubMed:33208952, PubMed:36113465). It is acted on by 1 drug in DrugBank.

Gene name
CTNS
UniProtKB entry
O60931Swiss-Prot
Cellular location
Lysosome membrane
Residues / weight
367 residues · 41,738 Da

Resolves to

Protein
UniProtO60931UniProt nameCTNS_HUMAN
Gene
HGNCHGNC:2518NCBI Gene1497GenBank3036851GeneCardsCTNS
Pharmacology
KEGGhsa:1497
Structure
PDB8DKEPDB8DKIPDB8DKM
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cystinosin, how selective are they, and which programs against it are still in active trials?

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