Transketolase

BE0000039ProteinHumansTKT

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (PubMed:20667822, PubMed:27259054, PubMed:31534226). It is acted on by 3 drugs in DrugBank.

Gene name
TKT
UniProtKB entry
P29401Swiss-Prot
Residues / weight
623 residues · 67,877 Da
Also known as
2.2.1.1 · TK

Resolves to

Protein
UniProtP29401UniProt nameTKT_HUMAN
Gene
HGNCHGNC:11834NCBI Gene7086GenBank37267GeneCardsTKT
Pharmacology
KEGGhsa:7086
Structure
PDB3MOSPDB3OOYPDB4KXU
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transketolase, how selective are they, and which programs against it are still in active trials?

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