Thiamine is a vitamin used to correct vitamin B1 deficiency. Thiamine or thiamin, also known as vitamin B1, is a colorless compound with the chemical formula C12H17N4OS.
- Mechanism
- Curator reviewed
It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic flux. Thiamine is mainly the transport form of the vitamin, while the active forms are phosphorylated thiamine derivatives. Natural derivatives of thiamine phosphate, such as thiamine monophosphate (ThMP), thiamine diphosphate (ThDP), also sometimes called thiamine pyrophosphate (TPP), thiamine triphosphate (ThTP), and thiamine triphosphate (AThTP), that act as coenzymes in addition to their each unique biological functions.
- Primary indication
- For the treatment of thiamine and niacin deficiency states, Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome, delirium, and peripheral neuritis.Curator reviewed · 22 structured indications
- Formula / weight
- C12H17N4OS · 265.355 g/mol (avg)
- First approval
- Canada, 1996 · United States, 2000
- Also known as
- Aneurin · Antiberiberi factor · thiamine(1+) · thiamine(1+) ion · Vitamin B 1
- Brand names
Resolves to
JZRWCGZRTZMZEH-UHFFFAOYSA-NSMILESCC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1NWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Thiamine, and which of those have an active Phase 3 trial?
Create a free account or log in to explore the full data card.
Create Account