Solute carrier family 12 member 5

BE0000047ProteinHumansSLC12A5

Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (PubMed:12106695). It is acted on by 2 drugs in DrugBank.

Gene name
SLC12A5
UniProtKB entry
Q9H2X9Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,139 residues · 126,182 Da
Also known as
Electroneutral potassium-chloride cotransporter 2 · hKCC2 · K-Cl cotransporter 2 · KCC2 · KIAA1176

Resolves to

Protein
UniProtQ9H2X9UniProt nameS12A5_HUMAN
Gene
HGNCHGNC:13818NCBI Gene57468GenBank12003227GeneCardsSLC12A5
Pharmacology
IUPHAR/GtoPdb972KEGGhsa:57468
Structure
PDB6M23PDB7D8Z
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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20GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier family 12 member 5, how selective are they, and which programs against it are still in active trials?

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